PCGF2

Entrez Summary: N/A
UniProt Summary: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). {ECO:0000250|UniProtKB:P23798, ECO:0000269|PubMed:26151332}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sex chromatin
histone H2A-K119 monoubiquitination
PRC1 complex
histone H2A monoubiquitination
histone H2A ubiquitination
PcG protein complex
histone monoubiquitination
negative regulation of G0 to G1 transition
histone ubiquitination
regulation of G0 to G1 transition
promoter-specific chromatin binding
chromatin organization involved in negative regulation of transcription
chromatin silencing
protein monoubiquitination
chromatin organization involved in regulation of transcription
cellular response to hydrogen peroxide
negative regulation of gene expression, epigenetic
embryonic skeletal system morphogenesis
histone acetylation
cellular response to antibiotic
response to hydrogen peroxide
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
embryonic skeletal system development
cellular response to reactive oxygen species
protein acetylation
gene silencing
protein acylation
response to reactive oxygen species
cellular response to toxic substance
anterior/posterior pattern specification
negative regulation of apoptotic signaling pathway
regulation of gene expression, epigenetic
nuclear chromatin
skeletal system morphogenesis
cellular response to oxidative stress
nuclear body
embryonic organ morphogenesis
response to antibiotic