PCGF6

Gene Information

Official Symbol: PCGF6
Official Name: polycomb group ring finger 6
Aliases and Previous Symbols: N/A
Entrez ID: 84108
UniProt: Q9BYE7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:26151332}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ribavirin 10 to 15μM on day4 R04 exp160	-2.64
Genistein 15μM R07 exp360	-1.71
Rapamycin 1μM R00 exp29	1.7
LY2090314 0.003μM R08 exp500 no dilution day6	1.72
Rapamycin 10μM R00 exp30	1.96
MLN-4924 0.2μM R00 exp21	2.02

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9335
Expression level (log2 read counts): 4.74

Expression Distribution

inactivation of X chromosome by genetic imprinting
histone H2A-K119 monoubiquitination
PRC1 complex
dosage compensation by inactivation of X chromosome
regulation of gene expression by genetic imprinting
histone H2A monoubiquitination
dosage compensation
genetic imprinting
histone H2A ubiquitination
PcG protein complex
histone monoubiquitination
negative regulation of G0 to G1 transition
histone ubiquitination
regulation of G0 to G1 transition
protein monoubiquitination
regulation of gene expression, epigenetic
DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II regulatory region sequence-specific DNA binding
negative regulation of cell cycle process
histone modification
covalent chromatin modification
negative regulation of cell cycle
DNA-binding transcription factor activity
protein ubiquitination
chromatin organization
regulation of cell cycle process
protein modification by small protein conjugation
negative regulation of transcription by RNA polymerase II
protein modification by small protein conjugation or removal
chromosome organization
regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process