PCID2 [The Human Chemical-Genetic Interaction Map Project]

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======= PCID2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCID2
  * **<color #00a2e8>Official Name</color>**: PCI domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55795|55795]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5JVF3|Q5JVF3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCID2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCID2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613713|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PCI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|
|transcription export complex 2|
|nuclear retention of pre-mRNA at the site of transcription|
|positive regulation of mitotic cell cycle spindle assembly checkpoint|
|positive regulation of spindle checkpoint|
|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|
|positive regulation of cell cycle checkpoint|
|intracellular mRNA localization|
|positive regulation of B cell differentiation|
|nuclear pore nuclear basket|
|nuclear RNA surveillance|
|regulation of mitotic cell cycle spindle assembly checkpoint|
|regulation of mitotic spindle checkpoint|
|nuclear mRNA surveillance|
|regulation of spindle checkpoint|
|RNA surveillance|
|poly(A)+ mRNA export from nucleus|
|transcriptionally active chromatin|
|regulation of B cell differentiation|
|regulation of cell cycle checkpoint|
|spleen development|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|transcription elongation from RNA polymerase II promoter|
|regulation of sister chromatid segregation|
|negative regulation of cysteine-type endopeptidase activity|
|DNA-templated transcription, elongation|
|positive regulation of lymphocyte differentiation|
|double-stranded DNA binding|
|regulation of chromosome segregation|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|positive regulation of leukocyte differentiation|
|protein export from nucleus|
|positive regulation of mitotic cell cycle|
|mRNA transport|
|nuclear export|
|positive regulation of B cell activation|
|regulation of mitotic nuclear division|
|regulation of lymphocyte differentiation|
|regulation of mRNA stability|
|regulation of RNA stability|
|positive regulation of hemopoiesis|
|regulation of nuclear division|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|regulation of B cell activation|
|mRNA catabolic process|
|RNA localization|
|nucleobase-containing compound transport|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|RNA catabolic process|
|negative regulation of peptidase activity|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of leukocyte differentiation|
|positive regulation of cell cycle process|
|regulation of mRNA metabolic process|
|regulation of chromosome organization|
|negative regulation of proteolysis|
|positive regulation of lymphocyte activation|
|nucleobase-containing compound catabolic process|
|positive regulation of cell cycle|
|positive regulation of leukocyte activation|
|regulation of mitotic cell cycle phase transition|
|regulation of endopeptidase activity|
|positive regulation of cell activation|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|cellular component|
|regulation of hemopoiesis|
|negative regulation of hydrolase activity|
|organic cyclic compound catabolic process|
|transcription by RNA polymerase II|
|regulation of lymphocyte activation|
|posttranscriptional regulation of gene expression|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|mRNA metabolic process|
|regulation of proteolysis|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|regulation of catabolic process|
|intracellular protein transport|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|regulation of hydrolase activity|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.16|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.87|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.79|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.73|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.485|
|[[:human genes:h:hars|HARS]]|0.433|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 438/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|20/28|
|blood|14/28|
|bone|15/26|
|breast|20/33|
|central nervous system|31/56|
|cervix|3/4|
|colorectal|13/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|10/21|
|liver|11/20|
|lung|57/75|
|lymphocyte|10/16|
|ovary|17/26|
|pancreas|18/24|
|peripheral nervous system|10/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|10/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|7/22|
|urinary tract|17/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 285
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCID2 Expression in NALM6 Cells: 6.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>