PCID2
Gene Information
- Official Symbol: PCID2
- Official Name: PCI domain containing 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 55795
- UniProt: Q5JVF3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PCI |
GO Terms
| posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery |
| transcription export complex 2 |
| nuclear retention of pre-mRNA at the site of transcription |
| positive regulation of mitotic cell cycle spindle assembly checkpoint |
| positive regulation of spindle checkpoint |
| transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery |
| positive regulation of cell cycle checkpoint |
| intracellular mRNA localization |
| positive regulation of B cell differentiation |
| nuclear pore nuclear basket |
| nuclear RNA surveillance |
| regulation of mitotic cell cycle spindle assembly checkpoint |
| regulation of mitotic spindle checkpoint |
| nuclear mRNA surveillance |
| regulation of spindle checkpoint |
| RNA surveillance |
| poly(A)+ mRNA export from nucleus |
| transcriptionally active chromatin |
| regulation of B cell differentiation |
| regulation of cell cycle checkpoint |
| spleen development |
| regulation of mitotic metaphase/anaphase transition |
| regulation of metaphase/anaphase transition of cell cycle |
| regulation of mitotic sister chromatid separation |
| regulation of chromosome separation |
| regulation of mitotic sister chromatid segregation |
| transcription elongation from RNA polymerase II promoter |
| regulation of sister chromatid segregation |
| negative regulation of cysteine-type endopeptidase activity |
| DNA-templated transcription, elongation |
| positive regulation of lymphocyte differentiation |
| double-stranded DNA binding |
| regulation of chromosome segregation |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| mRNA export from nucleus |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| positive regulation of leukocyte differentiation |
| protein export from nucleus |
| positive regulation of mitotic cell cycle |
| mRNA transport |
| nuclear export |
| positive regulation of B cell activation |
| regulation of mitotic nuclear division |
| regulation of lymphocyte differentiation |
| regulation of mRNA stability |
| regulation of RNA stability |
| positive regulation of hemopoiesis |
| regulation of nuclear division |
| nucleic acid transport |
| RNA transport |
| establishment of RNA localization |
| nuclear-transcribed mRNA catabolic process |
| regulation of mRNA catabolic process |
| regulation of B cell activation |
| mRNA catabolic process |
| RNA localization |
| nucleobase-containing compound transport |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| RNA catabolic process |
| negative regulation of peptidase activity |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| nuclear transport |
| regulation of leukocyte differentiation |
| positive regulation of cell cycle process |
| regulation of mRNA metabolic process |
| regulation of chromosome organization |
| negative regulation of proteolysis |
| positive regulation of lymphocyte activation |
| nucleobase-containing compound catabolic process |
| positive regulation of cell cycle |
| positive regulation of leukocyte activation |
| regulation of mitotic cell cycle phase transition |
| regulation of endopeptidase activity |
| positive regulation of cell activation |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| regulation of peptidase activity |
| regulation of cell cycle phase transition |
| cellular component |
| regulation of hemopoiesis |
| negative regulation of hydrolase activity |
| organic cyclic compound catabolic process |
| transcription by RNA polymerase II |
| regulation of lymphocyte activation |
| posttranscriptional regulation of gene expression |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| regulation of mitotic cell cycle |
| regulation of cell activation |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| immune system development |
| RNA biosynthetic process |
| mRNA metabolic process |
| regulation of proteolysis |
| regulation of cell cycle process |
| negative regulation of catalytic activity |
| regulation of cellular catabolic process |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| cellular macromolecule catabolic process |
| positive regulation of cell differentiation |
| negative regulation of cell death |
| regulation of catabolic process |
| intracellular protein transport |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| positive regulation of immune system process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| regulation of hydrolase activity |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| positive regulation of developmental process |
| RNA binding |
| protein transport |
| intracellular transport |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| RNA metabolic process |
| regulation of cell death |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| establishment of localization in cell |
| nitrogen compound transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Mdivi-1 15μM R05 exp217 | -2.16 |
| Lead acetate 2000μM R08 exp498 no dilution day6 | -1.87 |
| Cerivastatin 0.15μM R05 exp226 | -1.79 |
| S-DABN 8μM R03 exp112 | 1.73 |
| LB-100 4.1μM R02 exp72 | 1.84 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 438/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 20/28 |
| blood | 14/28 |
| bone | 15/26 |
| breast | 20/33 |
| central nervous system | 31/56 |
| cervix | 3/4 |
| colorectal | 13/17 |
| esophagus | 6/13 |
| fibroblast | 0/1 |
| gastric | 10/16 |
| kidney | 10/21 |
| liver | 11/20 |
| lung | 57/75 |
| lymphocyte | 10/16 |
| ovary | 17/26 |
| pancreas | 18/24 |
| peripheral nervous system | 10/16 |
| plasma cell | 9/15 |
| prostate | 1/1 |
| skin | 10/24 |
| soft tissue | 5/9 |
| thyroid | 2/2 |
| upper aerodigestive | 7/22 |
| urinary tract | 17/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 285
- Expression level (log2 read counts): 6.57
Expression Distribution
PCID2 Expression in NALM6 Cells: 6.57
