PCLO

Entrez Summary: The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
UniProt Summary: May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. {ECO:0000250|UniProtKB:Q9QYX7}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Aminopterin 0.005μM R07 exp335	-1.94
DABN 2μM R00 exp16	1.9

presynaptic signal transduction
presynapse to nucleus signaling pathway
structural constituent of presynaptic active zone
maintenance of presynaptic active zone structure
cytoskeleton of presynaptic active zone
presynaptic active zone organization
synaptic vesicle clustering
profilin binding
maintenance of synapse structure
insulin secretion
synaptic vesicle localization
cellular component maintenance
calcium-dependent phospholipid binding
peptide hormone secretion
protein localization to synapse
synaptic vesicle exocytosis
hormone secretion
hormone transport
synapse assembly
signal release from synapse
neurotransmitter secretion
synaptic vesicle cycle
vesicle-mediated transport in synapse
cAMP-mediated signaling
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
signal release
cyclic-nucleotide-mediated signaling
peptide secretion
neurotransmitter transport
vesicle localization
regulation of exocytosis
postsynaptic density
synapse
synapse organization
second-messenger-mediated signaling
regulation of neurotransmitter levels
cytoskeleton
chemical synaptic transmission