PDCD2

Gene Information

Official Symbol: PDCD2
Official Name: programmed cell death 2
Aliases and Previous Symbols: N/A
Entrez ID: 5134
UniProt: Q16342
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 653/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	25/28
blood	23/28
bone	25/26
breast	27/33
central nervous system	55/56
cervix	4/4
colorectal	14/17
esophagus	9/13
fibroblast	1/1
gastric	14/16
kidney	20/21
liver	18/20
lung	62/75
lymphocyte	12/16
ovary	23/26
pancreas	21/24
peripheral nervous system	13/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	18/22
urinary tract	29/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 956
Expression level (log2 read counts): 6.67

Expression Distribution

zf-MYND
PDCD2 C

positive regulation of hematopoietic stem cell proliferation
regulation of hematopoietic stem cell proliferation
positive regulation of stem cell proliferation
regulation of stem cell proliferation
regulation of hematopoietic progenitor cell differentiation
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity
positive regulation of endopeptidase activity
positive regulation of hemopoiesis
positive regulation of peptidase activity
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
enzyme binding
positive regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
regulation of hemopoiesis
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of proteolysis
positive regulation of hydrolase activity
positive regulation of cell population proliferation
apoptotic process
programmed cell death
cell death
positive regulation of immune system process
regulation of hydrolase activity
positive regulation of developmental process
positive regulation of catalytic activity
DNA binding
regulation of apoptotic process
regulation of programmed cell death
positive regulation of cellular protein metabolic process
regulation of cell population proliferation
regulation of immune system process
regulation of cell death
positive regulation of protein metabolic process
positive regulation of multicellular organismal process