PDE12 [The Human Chemical-Genetic Interaction Map Project]

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======= PDE12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDE12
  * **<color #00a2e8>Official Name</color>**: phosphodiesterase 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=201626|201626]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6L8Q7|Q6L8Q7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDE12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDE12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616519|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Exo endo phos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oligoribonucleotidase activity|
|mitochondrial mRNA catabolic process|
|mitochondrial RNA catabolic process|
|regulation of mitochondrial mRNA stability|
|negative regulation of oxidative phosphorylation|
|cellular response to interferon-alpha|
|poly(A)-specific ribonuclease activity|
|exonuclease activity|
|response to interferon-alpha|
|cellular response to dsRNA|
|negative regulation of ATP metabolic process|
|regulation of oxidative phosphorylation|
|3-5-exoribonuclease activity|
|positive regulation of viral genome replication|
|mitochondrial RNA metabolic process|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|response to dsRNA|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|positive regulation of viral life cycle|
|regulation of viral genome replication|
|positive regulation of viral process|
|regulation of ATP metabolic process|
|regulation of viral life cycle|
|regulation of generation of precursor metabolites and energy|
|RNA phosphodiester bond hydrolysis|
|cellular response to interferon-gamma|
|regulation of mRNA stability|
|response to interferon-gamma|
|regulation of RNA stability|
|defense response to virus|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|regulation of viral process|
|mRNA catabolic process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|RNA catabolic process|
|response to virus|
|nucleic acid phosphodiester bond hydrolysis|
|regulation of mRNA metabolic process|
|mitochondrial matrix|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|negative regulation of phosphorylation|
|mRNA processing|
|organic cyclic compound catabolic process|
|positive regulation of multi-organism process|
|posttranscriptional regulation of gene expression|
|cellular response to organic cyclic compound|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|cellular response to nitrogen compound|
|mRNA metabolic process|
|innate immune response|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|RNA processing|
|cellular macromolecule catabolic process|
|response to organic cyclic compound|
|defense response to other organism|
|negative regulation of cell death|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|macromolecule catabolic process|
|response to nitrogen compound|
|immune effector process|
|response to cytokine|
|mitochondrion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of phosphorylation|
|RNA metabolic process|
|regulation of cell death|
|negative regulation of gene expression|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|immune response|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.7|
|[[:results:exp302|35°C R06 exp302]]|1.71|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.77|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.79|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.79|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.83|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.86|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.88|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.94|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.06|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.12|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.15|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.21|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.24|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.31|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.45|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufb10|NDUFB10]]|0.589|
|[[:human genes:n:nsun4|NSUN4]]|0.585|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.555|
|[[:human genes:m:mto1|MTO1]]|0.546|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.537|
|[[:human genes:a:acad9|ACAD9]]|0.526|
|[[:human genes:p:prepl|PREPL]]|0.524|
|[[:human genes:n:nubpl|NUBPL]]|0.513|
|[[:human genes:f:fastkd2|FASTKD2]]|0.502|
|[[:human genes:m:malsu1|MALSU1]]|0.498|
|[[:human genes:e:eral1|ERAL1]]|0.496|
|[[:human genes:m:mtif2|MTIF2]]|0.488|
|[[:human genes:s:sfxn4|SFXN4]]|0.481|
|[[:human genes:n:ndufb7|NDUFB7]]|0.48|
|[[:human genes:g:grsf1|GRSF1]]|0.479|
|[[:human genes:s:slc30a9|SLC30A9]]|0.477|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.473|
|[[:human genes:n:ndufv2|NDUFV2]]|0.461|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.459|
|[[:human genes:y:ybey|YBEY]]|0.458|
|[[:human genes:m:mrps18b|MRPS18B]]|0.457|
|[[:human genes:s:ssbp1|SSBP1]]|0.457|
|[[:human genes:m:mcat|MCAT]]|0.457|
|[[:human genes:p:pet117|PET117]]|0.455|
|[[:human genes:t:tsfm|TSFM]]|0.453|
|[[:human genes:n:ndufs2|NDUFS2]]|0.451|
|[[:human genes:r:rmnd1|RMND1]]|0.448|
|[[:human genes:m:mrps27|MRPS27]]|0.443|
|[[:human genes:m:mcur1|MCUR1]]|0.437|
|[[:human genes:c:clpx|CLPX]]|0.436|
|[[:human genes:n:ndufs5|NDUFS5]]|0.433|
|[[:human genes:c:chchd1|CHCHD1]]|0.429|
|[[:human genes:p:pet112|PET112]]|0.425|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.415|
|[[:human genes:m:mettl17|METTL17]]|0.415|
|[[:human genes:n:ndufb11|NDUFB11]]|0.414|
|[[:human genes:l:lrr1|LRR1]]|0.409|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.408|
|[[:human genes:n:ndufa9|NDUFA9]]|0.408|
|[[:human genes:n:ndufb9|NDUFB9]]|0.407|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.405|
|[[:human genes:r:rexo2|REXO2]]|0.405|
|[[:human genes:n:ndufa1|NDUFA1]]|0.402|
|[[:human genes:f:ftsj2|FTSJ2]]|0.402|
|[[:human genes:d:ddx28|DDX28]]|0.402|
|[[:human genes:c:cox6a1|COX6A1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 23/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|3/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 823
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDE12 Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>