PDE12

Entrez Summary: N/A
UniProt Summary: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Temozolomide 200μM R04 exp189	1.7
35°C R06 exp302	1.71
Genistein 15μM R07 exp360	1.77
Vemurafenib 6.6μM R02 exp89	1.79
UMK57 1μM R01 exp59	1.79
MK-1775 0.32μM R02 exp75	1.83
Clomiphene 4.4μM R02 exp68	1.86
FK-506 30μM R07 exp359	1.88
Oligomycin-A 2μM R00 exp25	1.94
Hydroxyurea 100μM R07 exp329	2.06
Ribavirin 10 to 15μM on day4 R04 exp160	2.12
Vinblastine 0.002μM R01 exp60	2.15
HMS-I1 1μM R01 exp46	2.21
Mubritinib 0.2μM R01 exp48	2.24
Artemisinin 50μM R08 exp450	2.31
Chloroquine 32μM R08 exp470	2.45
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.52

Global Fraction of Cell Lines Where Essential: 23/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	2/13
fibroblast	0/1
gastric	1/16
kidney	2/21
liver	3/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

oligoribonucleotidase activity
mitochondrial mRNA catabolic process
mitochondrial RNA catabolic process
regulation of mitochondrial mRNA stability
negative regulation of oxidative phosphorylation
cellular response to interferon-alpha
poly(A)-specific ribonuclease activity
exonuclease activity
response to interferon-alpha
cellular response to dsRNA
negative regulation of ATP metabolic process
regulation of oxidative phosphorylation
3-5-exoribonuclease activity
positive regulation of viral genome replication
mitochondrial RNA metabolic process
RNA phosphodiester bond hydrolysis, exonucleolytic
response to dsRNA
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of viral life cycle
regulation of viral genome replication
positive regulation of viral process
regulation of ATP metabolic process
regulation of viral life cycle
regulation of generation of precursor metabolites and energy
RNA phosphodiester bond hydrolysis
cellular response to interferon-gamma
regulation of mRNA stability
response to interferon-gamma
regulation of RNA stability
defense response to virus
nuclear-transcribed mRNA catabolic process
regulation of mRNA catabolic process
regulation of viral process
mRNA catabolic process
regulation of symbiosis, encompassing mutualism through parasitism
RNA catabolic process
response to virus
nucleic acid phosphodiester bond hydrolysis
regulation of mRNA metabolic process
mitochondrial matrix