PDE1A

Gene Information

Official Symbol: PDE1A
Official Name: phosphodiesterase 1A
Aliases and Previous Symbols: N/A
Entrez ID: 5136
UniProt: P54750
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9675
Expression level (log2 read counts): -1.24

Expression Distribution

PDEase I
PDEase I N

calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
calcium- and calmodulin-regulated 3,5-cyclic-GMP phosphodiesterase activity
cGMP catabolic process
cyclic nucleotide catabolic process
cGMP metabolic process
regulation of smooth muscle cell apoptotic process
purine ribonucleotide catabolic process
ribonucleotide catabolic process
cyclic nucleotide metabolic process
purine nucleotide catabolic process
purine-containing compound catabolic process
nucleotide catabolic process
regulation of muscle cell apoptotic process
nucleoside phosphate catabolic process
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
regulation of smooth muscle cell proliferation
carbohydrate derivative catabolic process
calmodulin binding
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
neuronal cell body
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
organophosphate metabolic process
carbohydrate derivative metabolic process
organonitrogen compound catabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process