PDE1B [The Human Chemical-Genetic Interaction Map Project]

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======= PDE1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDE1B
  * **<color #00a2e8>Official Name</color>**: phosphodiesterase 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5153|5153]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01064|Q01064]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDE1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDE1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/171891|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. {ECO:0000269|PubMed:15260978}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDEase I N|
|PDEase I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium- and calmodulin-regulated 3,5-cyclic-GMP phosphodiesterase activity|
|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|
|response to macrophage colony-stimulating factor|
|cellular response to macrophage colony-stimulating factor stimulus|
|response to granulocyte macrophage colony-stimulating factor|
|cellular response to granulocyte macrophage colony-stimulating factor stimulus|
|serotonin metabolic process|
|3,5-cyclic-AMP phosphodiesterase activity|
|primary amino compound metabolic process|
|3,5-cyclic-GMP phosphodiesterase activity|
|mononuclear cell differentiation|
|monocyte differentiation|
|regulation of dopamine metabolic process|
|regulation of catecholamine metabolic process|
|indole-containing compound metabolic process|
|response to amphetamine|
|response to amine|
|visual learning|
|response to bronchodilator|
|visual behavior|
|associative learning|
|regulation of cellular amine metabolic process|
|phenol-containing compound metabolic process|
|neurotransmitter metabolic process|
|myeloid leukocyte differentiation|
|learning|
|ammonium ion metabolic process|
|locomotory behavior|
|calmodulin binding|
|myeloid cell differentiation|
|learning or memory|
|cognition|
|response to xenobiotic stimulus|
|response to light stimulus|
|leukocyte differentiation|
|regulation of neurotransmitter levels|
|neuronal cell body|
|response to radiation|
|organic hydroxy compound metabolic process|
|response to toxic substance|
|hemopoiesis|
|behavior|
|hematopoietic or lymphoid organ development|
|immune system development|
|apoptotic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|programmed cell death|
|response to nitrogen compound|
|cell death|
|response to cytokine|
|response to abiotic stimulus|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3023
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDE1B Expression in NALM6 Cells: 4.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>