PDE1B

Entrez Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].
UniProt Summary: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. {ECO:0000269|PubMed:15260978}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PDEase I N
PDEase I

calcium- and calmodulin-regulated 3,5-cyclic-GMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
response to macrophage colony-stimulating factor
cellular response to macrophage colony-stimulating factor stimulus
response to granulocyte macrophage colony-stimulating factor
cellular response to granulocyte macrophage colony-stimulating factor stimulus
serotonin metabolic process
3,5-cyclic-AMP phosphodiesterase activity
primary amino compound metabolic process
3,5-cyclic-GMP phosphodiesterase activity
mononuclear cell differentiation
monocyte differentiation
regulation of dopamine metabolic process
regulation of catecholamine metabolic process
indole-containing compound metabolic process
response to amphetamine
response to amine
visual learning
response to bronchodilator
visual behavior
associative learning
regulation of cellular amine metabolic process
phenol-containing compound metabolic process
neurotransmitter metabolic process
myeloid leukocyte differentiation
learning
ammonium ion metabolic process
locomotory behavior
calmodulin binding
myeloid cell differentiation
learning or memory
cognition
response to xenobiotic stimulus
response to light stimulus
leukocyte differentiation
regulation of neurotransmitter levels
neuronal cell body
response to radiation
organic hydroxy compound metabolic process
response to toxic substance