PDE3B

Entrez Summary: N/A
UniProt Summary: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. {ECO:0000269|PubMed:15147193, ECO:0000269|PubMed:21393242}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ONC212 0.15μM R08 exp513	-2.09
SGC2043 10μM R03 exp152	1.8
Dexamethasone 0.006μM R07 exp351	1.84
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.85
Zebularine 20μM R07 exp423	1.88
ABT-702 5μM R07 exp318	1.91

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
3,5-cyclic-nucleotide phosphodiesterase activity
negative regulation of cell adhesion mediated by integrin
guanyl-nucleotide exchange factor complex
protein kinase B binding
3,5-cyclic-AMP phosphodiesterase activity
negative regulation of lipid catabolic process
negative regulation of cAMP-mediated signaling
regulation of cell adhesion mediated by integrin
regulation of cAMP-mediated signaling
regulation of lipid catabolic process
negative regulation of lipid metabolic process
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
cellular response to insulin stimulus
response to insulin
cellular response to peptide hormone stimulus
negative regulation of cell adhesion
regulation of angiogenesis
negative regulation of catabolic process
angiogenesis
regulation of vasculature development
cellular response to peptide
response to peptide hormone
regulation of lipid metabolic process
blood vessel morphogenesis
response to peptide
blood vessel development
negative regulation of intracellular signal transduction
vasculature development
cardiovascular system development
cellular response to organonitrogen compound
cellular response to hormone stimulus
tube morphogenesis
cellular response to nitrogen compound
regulation of cell adhesion
tube development
circulatory system development
anatomical structure formation involved in morphogenesis