PDE8A [The Human Chemical-Genetic Interaction Map Project]

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======= PDE8A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDE8A
  * **<color #00a2e8>Official Name</color>**: phosphodiesterase 8A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5151|5151]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60658|O60658]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDE8A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDE8A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602972|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDEase I|
|PAS|
|Response reg|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cAMP catabolic process|
|3,5-cyclic-AMP phosphodiesterase activity|
|cyclic nucleotide catabolic process|
|3,5-cyclic-GMP phosphodiesterase activity|
|negative regulation of hydrogen peroxide-induced cell death|
|negative regulation of response to reactive oxygen species|
|negative regulation of cellular response to drug|
|cAMP metabolic process|
|regulation of hydrogen peroxide-induced cell death|
|negative regulation of response to drug|
|purine ribonucleotide catabolic process|
|ribonucleotide catabolic process|
|regulation of response to reactive oxygen species|
|regulation of cellular response to drug|
|cyclic nucleotide metabolic process|
|cellular response to epidermal growth factor stimulus|
|purine nucleotide catabolic process|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of cellular response to oxidative stress|
|negative regulation of response to oxidative stress|
|response to epidermal growth factor|
|purine-containing compound catabolic process|
|regulation of oxidative stress-induced cell death|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|regulation of cellular response to oxidative stress|
|regulation of response to oxidative stress|
|kinase binding|
|regulation of response to drug|
|nucleobase-containing small molecule biosynthetic process|
|organophosphate catabolic process|
|carbohydrate derivative catabolic process|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of ERK1 and ERK2 cascade|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|cellular response to growth factor stimulus|
|response to growth factor|
|nucleobase-containing small molecule metabolic process|
|positive regulation of MAPK cascade|
|small molecule biosynthetic process|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|organophosphate metabolic process|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.84|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.82|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.94|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14032
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDE8A Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>