PDE8A

Gene Information

Official Symbol: PDE8A
Official Name: phosphodiesterase 8A
Aliases and Previous Symbols: N/A
Entrez ID: 5151
UniProt: O60658
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SGC2096 2.6μM R03 exp153	-1.84
Pterostilbene 16μM R02 exp78	1.82
Menadione 5μM R06 exp292	1.94
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	2.06

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14032
Expression level (log2 read counts): 5.46

Expression Distribution

PDEase I
PAS
Response reg

cAMP catabolic process
3,5-cyclic-AMP phosphodiesterase activity
cyclic nucleotide catabolic process
3,5-cyclic-GMP phosphodiesterase activity
negative regulation of hydrogen peroxide-induced cell death
negative regulation of response to reactive oxygen species
negative regulation of cellular response to drug
cAMP metabolic process
regulation of hydrogen peroxide-induced cell death
negative regulation of response to drug
purine ribonucleotide catabolic process
ribonucleotide catabolic process
regulation of response to reactive oxygen species
regulation of cellular response to drug
cyclic nucleotide metabolic process
cellular response to epidermal growth factor stimulus
purine nucleotide catabolic process
negative regulation of oxidative stress-induced cell death
negative regulation of cellular response to oxidative stress
negative regulation of response to oxidative stress
response to epidermal growth factor
purine-containing compound catabolic process
regulation of oxidative stress-induced cell death
nucleotide catabolic process
nucleoside phosphate catabolic process
regulation of cellular response to oxidative stress
regulation of response to oxidative stress
kinase binding
regulation of response to drug
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
carbohydrate derivative catabolic process
positive regulation of ERK1 and ERK2 cascade
regulation of ERK1 and ERK2 cascade
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleobase-containing compound catabolic process