PDLIM2
Gene Information
- Official Symbol: PDLIM2
- Official Name: PDZ and LIM domain 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 64236
- UniProt: Q96JY6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011].
- UniProt Summary: Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8833
- Expression level (log2 read counts): 3.95
PDLIM2 Expression in NALM6 Cells: 3.95
