PDS5A [The Human Chemical-Genetic Interaction Map Project]

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======= PDS5A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDS5A
  * **<color #00a2e8>Official Name</color>**: PDS5 cohesin associated factor A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23244|23244]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q29RF7|Q29RF7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDS5A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDS5A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613200|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic sister chromatid cohesion|
|negative regulation of DNA replication|
|sister chromatid cohesion|
|chromosome, centromeric region|
|regulation of DNA replication|
|mitotic sister chromatid segregation|
|chromatin|
|chromosome|
|sister chromatid segregation|
|mitotic nuclear division|
|nuclear chromosome segregation|
|chromosome segregation|
|nuclear division|
|organelle fission|
|cell division|
|DNA repair|
|mitotic cell cycle process|
|mitotic cell cycle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cell cycle process|
|chromosome organization|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.02|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.93|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.75|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.74|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.71|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.78|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.79|
|[[:results:exp453|B02 10μM R08 exp453]]|1.81|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.93|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.04|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.07|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.16|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.27|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.36|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.49|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|3.27|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.61|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|4.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cd19|CD19]]|0.494|
|[[:human genes:r:rhoh|RHOH]]|0.491|
|[[:human genes:d:ddx3x|DDX3X]]|0.446|
|[[:human genes:p:prim1|PRIM1]]|0.44|
|[[:human genes:b:bcl2l11|BCL2L11]]|0.412|
|[[:human genes:p:pik3cd|PIK3CD]]|0.409|
|[[:human genes:a:arrdc3|ARRDC3]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 43/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|4/28|
|bone|0/25|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|3/21|
|liver|2/20|
|lung|3/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19051
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDS5A Expression in NALM6 Cells: 8.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>