PDS5A

Entrez Summary: The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010].
UniProt Summary: Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cytochalasin-B 5μM R07 exp349	-2.02
Pimelic-diphenylamide-106 5μM R00 exp28	-1.93
Vemurafenib 6.6μM R02 exp89	-1.75
Etoposide 0.3μM R05 exp199	-1.74
IU1-C 25μM R04 exp183	1.71
Cerivastatin 0.15μM R05 exp226	1.78
Trimetrexate 0.03μM R08 exp535	1.79
B02 10μM R08 exp453	1.81
ZLN024 50μM R08 exp538	1.93
JQ1 0.8μM R08 exp435	2.04
AICAR 240μM R03 exp116	2.07
Bisphenol S 100μM R08 exp458	2.16
iCRT14 30μM R08 exp492	2.27
MS023 7μM R03 exp135	2.36
MS023 2μM R03 exp134	2.49
LY2090314 0.003μM R08 exp500 no dilution day6	3.27
LY2090314 0.003μM R08 exp499	3.61
Ethanol 0.01 R05 exp234	4.51

Global Fraction of Cell Lines Where Essential: 43/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	4/28
bone	0/25
breast	1/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/15
kidney	3/21
liver	2/20
lung	3/75
lymphocyte	0/14
ovary	1/26
pancreas	2/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	4/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	3/29
uterus	0/5

Expression Distribution

mitotic sister chromatid cohesion
negative regulation of DNA replication
sister chromatid cohesion
chromosome, centromeric region
regulation of DNA replication
mitotic sister chromatid segregation
chromatin
chromosome
sister chromatid segregation
mitotic nuclear division
nuclear chromosome segregation
chromosome segregation
nuclear division
organelle fission
cell division
DNA repair
mitotic cell cycle process
mitotic cell cycle
DNA metabolic process
cellular response to DNA damage stimulus
cell cycle process
chromosome organization
cell cycle
negative regulation of cellular macromolecule biosynthetic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
cellular response to stress