PDZD3

Gene Information

Official Symbol: PDZD3
Official Name: PDZ domain containing 3
Aliases and Previous Symbols: N/A
Entrez ID: 79849
UniProt: Q86UT5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6449
Expression level (log2 read counts): -5.01

Expression Distribution

guanylate cyclase inhibitor activity
subapical complex
negative regulation of guanylate cyclase activity
negative regulation of purine nucleotide biosynthetic process
negative regulation of nucleotide biosynthetic process
negative regulation of cGMP-mediated signaling
ion channel inhibitor activity
receptor guanylyl cyclase signaling pathway
regulation of guanylate cyclase activity
regulation of cGMP-mediated signaling
ubiquitin-specific protease binding
negative regulation of purine nucleotide metabolic process
negative regulation of nucleotide metabolic process
water transport
negative regulation of cyclase activity
negative regulation of lyase activity
fluid transport
regulation of purine nucleotide biosynthetic process
regulation of nucleotide biosynthetic process
regulation of cyclase activity
regulation of lyase activity
brush border
apical part of cell
negative regulation of small molecule metabolic process
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
protein C-terminus binding
regulation of small molecule metabolic process
response to toxic substance
negative regulation of intracellular signal transduction
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
enzyme linked receptor protein signaling pathway
negative regulation of catalytic activity
negative regulation of molecular function
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
ion transport
negative regulation of nucleobase-containing compound metabolic process