PENK [The Human Chemical-Genetic Interaction Map Project]

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======= PENK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PENK
  * **<color #00a2e8>Official Name</color>**: proenkephalin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5179|5179]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01210|P01210]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PENK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PENK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131330|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Opiods neuropep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|synaptic vesicle lumen|
|neuronal dense core vesicle lumen|
|general adaptation syndrome, behavioral process|
|synaptic signaling via neuropeptide|
|general adaptation syndrome|
|opioid receptor binding|
|opioid peptide activity|
|symmetric synapse|
|positive regulation of behavioral fear response|
|cell body fiber|
|positive regulation of fear response|
|aggressive behavior|
|regulation of fear response|
|regulation of behavioral fear response|
|locomotory exploration behavior|
|cellular response to vitamin D|
|response to epinephrine|
|glial cell proliferation|
|cellular response to vitamin|
|exploration behavior|
|startle response|
|positive regulation of behavior|
|neuropeptide hormone activity|
|behavioral fear response|
|response to vitamin D|
|behavioral defense response|
|cellular response to virus|
|response to isoquinoline alkaloid|
|fear response|
|response to morphine|
|response to nicotine|
|axon terminus|
|cellular response to cAMP|
|cellular response to nutrient|
|multi-organism behavior|
|multicellular organismal response to stress|
|regulation of behavior|
|sensory perception of pain|
|response to anesthetic|
|response to vitamin|
|response to cAMP|
|response to monoamine|
|response to catecholamine|
|neuropeptide signaling pathway|
|neuromuscular process|
|response to alkaloid|
|osteoblast differentiation|
|response to ethanol|
|perikaryon|
|response to estradiol|
|response to organophosphorus|
|response to calcium ion|
|response to purine-containing compound|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|response to ammonium ion|
|locomotory behavior|
|gliogenesis|
|response to nutrient|
|response to alcohol|
|cellular response to nutrient levels|
|cellular response to oxidative stress|
|ossification|
|cellular response to extracellular stimulus|
|aging|
|response to virus|
|response to xenobiotic stimulus|
|endoplasmic reticulum lumen|
|response to antibiotic|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|cellular response to external stimulus|
|response to hypoxia|
|response to decreased oxygen levels|
|post-translational protein modification|
|response to metal ion|
|neuronal cell body|
|response to oxygen levels|
|response to oxidative stress|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|trans-synaptic signaling|
|response to radiation|
|synaptic signaling|
|positive regulation of defense response|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|response to toxic substance|
|cellular response to lipid|
|response to growth factor|
|response to extracellular stimulus|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|cell population proliferation|
|behavior|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|response to bacterium|
|regulation of defense response|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|sensory perception|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell-cell signaling|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|nervous system process|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|neurogenesis|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp303|39°C R06 exp303]]|-1.75|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16525
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PENK Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>