PENK
Gene Information
- Official Symbol: PENK
- Official Name: proenkephalin
- Aliases and Previous Symbols: N/A
- Entrez ID: 5179
- UniProt: P01210
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
Pfam Domains GO Terms
Pfam Domains
| Opiods neuropep |
GO Terms
| synaptic vesicle lumen |
| neuronal dense core vesicle lumen |
| general adaptation syndrome, behavioral process |
| synaptic signaling via neuropeptide |
| general adaptation syndrome |
| opioid receptor binding |
| opioid peptide activity |
| symmetric synapse |
| positive regulation of behavioral fear response |
| cell body fiber |
| positive regulation of fear response |
| aggressive behavior |
| regulation of fear response |
| regulation of behavioral fear response |
| locomotory exploration behavior |
| cellular response to vitamin D |
| response to epinephrine |
| glial cell proliferation |
| cellular response to vitamin |
| exploration behavior |
| startle response |
| positive regulation of behavior |
| neuropeptide hormone activity |
| behavioral fear response |
| response to vitamin D |
| behavioral defense response |
| cellular response to virus |
| response to isoquinoline alkaloid |
| fear response |
| response to morphine |
| response to nicotine |
| axon terminus |
| cellular response to cAMP |
| cellular response to nutrient |
| multi-organism behavior |
| multicellular organismal response to stress |
| regulation of behavior |
| sensory perception of pain |
| response to anesthetic |
| response to vitamin |
| response to cAMP |
| response to monoamine |
| response to catecholamine |
| neuropeptide signaling pathway |
| neuromuscular process |
| response to alkaloid |
| osteoblast differentiation |
| response to ethanol |
| perikaryon |
| response to estradiol |
| response to organophosphorus |
| response to calcium ion |
| response to purine-containing compound |
| cellular response to transforming growth factor beta stimulus |
| response to transforming growth factor beta |
| response to ammonium ion |
| locomotory behavior |
| gliogenesis |
| response to nutrient |
| response to alcohol |
| cellular response to nutrient levels |
| cellular response to oxidative stress |
| ossification |
| cellular response to extracellular stimulus |
| aging |
| response to virus |
| response to xenobiotic stimulus |
| endoplasmic reticulum lumen |
| response to antibiotic |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| cellular response to external stimulus |
| response to hypoxia |
| response to decreased oxygen levels |
| post-translational protein modification |
| response to metal ion |
| neuronal cell body |
| response to oxygen levels |
| response to oxidative stress |
| anterograde trans-synaptic signaling |
| dendrite |
| chemical synaptic transmission |
| trans-synaptic signaling |
| response to radiation |
| synaptic signaling |
| positive regulation of defense response |
| response to nutrient levels |
| cellular response to growth factor stimulus |
| response to toxic substance |
| cellular response to lipid |
| response to growth factor |
| response to extracellular stimulus |
| response to inorganic substance |
| cellular response to organic cyclic compound |
| cell population proliferation |
| behavior |
| cellular response to organonitrogen compound |
| cellular response to nitrogen compound |
| response to bacterium |
| regulation of defense response |
| response to lipid |
| response to hormone |
| response to organic cyclic compound |
| sensory perception |
| response to organonitrogen compound |
| response to drug |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| cell-cell signaling |
| response to abiotic stimulus |
| cellular response to endogenous stimulus |
| response to other organism |
| response to external biotic stimulus |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| nervous system process |
| response to endogenous stimulus |
| regulation of response to stress |
| response to oxygen-containing compound |
| neurogenesis |
| cellular response to stress |
| positive regulation of multicellular organismal process |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| 39°C R06 exp303 | -1.75 |
| Mubritinib 0.2μM R01 exp48 | 2.11 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16525
- Expression level (log2 read counts): -6.6
Expression Distribution
PENK Expression in NALM6 Cells: -6.6
