PERP [The Human Chemical-Genetic Interaction Map Project]

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======= PERP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PERP
  * **<color #00a2e8>Official Name</color>**: p53 apoptosis effector related to PMP22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64065|64065]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96FX8|Q96FX8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PERP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PERP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609301|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PMP22 Claudin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|desmosome organization|
|activation of cysteine-type endopeptidase activity|
|amelogenesis|
|desmosome|
|heterotypic cell-cell adhesion|
|zymogen activation|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|odontogenesis of dentin-containing tooth|
|cornification|
|odontogenesis|
|signal transduction by p53 class mediator|
|Notch signaling pathway|
|cell-cell junction organization|
|intrinsic apoptotic signaling pathway|
|positive regulation of cysteine-type endopeptidase activity|
|protein processing|
|positive regulation of endopeptidase activity|
|positive regulation of peptidase activity|
|cell junction organization|
|protein maturation|
|keratinization|
|regulation of cysteine-type endopeptidase activity|
|keratinocyte differentiation|
|apoptotic signaling pathway|
|epidermal cell differentiation|
|positive regulation of proteolysis|
|skin development|
|epidermis development|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|cell-cell adhesion|
|cell junction|
|epithelial cell differentiation|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|anatomical structure formation involved in morphogenesis|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|Golgi apparatus|
|programmed cell death|
|cell death|
|epithelium development|
|mitochondrion|
|proteolysis|
|regulation of hydrolase activity|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8401
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PERP Expression in NALM6 Cells: -1.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>