PEX2

Entrez Summary: This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. Mutations in this gene result in one form of Zellweger syndrome and infantile Refsum disease. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
UniProt Summary: Somewhat implicated in the biogenesis of peroxisomes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bisphenol F 50μM R08 exp457	-1.85
Lapatinib 5μM R01 exp47	1.71
Epigallocatechin gallate 20μM R05 exp230	1.73
Cerivastatin 0.15μM R05 exp226	1.75
Mubritinib 0.2μM R01 exp48	2
Fluvastatin 2.2μM R06 exp282	3.15

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-C3HC4
Pex2 Pex12

Cdc73/Paf1 complex
protein import into peroxisome matrix
integral component of peroxisomal membrane
peroxisomal membrane transport
negative regulation of fibroblast proliferation
very long-chain fatty acid metabolic process
protein transmembrane import into intracellular organelle
protein destabilization
intracellular protein transmembrane transport
fatty acid beta-oxidation
peroxisomal membrane
protein transmembrane transport
establishment of protein localization to peroxisome
protein localization to peroxisome
protein targeting to peroxisome
peroxisomal transport
fatty acid oxidation
lipid oxidation
peroxisome organization
regulation of fibroblast proliferation
fatty acid catabolic process
monocarboxylic acid catabolic process
negative regulation of epithelial cell proliferation
protein import
cellular lipid catabolic process
lipid modification
carboxylic acid catabolic process
organic acid catabolic process
regulation of protein stability
lipid catabolic process
fatty acid metabolic process
regulation of epithelial cell proliferation
protein targeting
establishment of protein localization to organelle
small molecule catabolic process
monocarboxylic acid metabolic process
negative regulation of cell population proliferation
protein ubiquitination
protein localization to organelle
protein modification by small protein conjugation