PF4

Gene Information

Official Symbol: PF4
Official Name: platelet factor 4
Aliases and Previous Symbols: N/A
Entrez ID: 5196
UniProt: P02776
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014].
UniProt Summary: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. {ECO:0000269|PubMed:7644496}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5186
Expression level (log2 read counts): -7.68

Expression Distribution

host cell cytoplasm
CXCR3 chemokine receptor binding
negative regulation of megakaryocyte differentiation
negative regulation of MHC class II biosynthetic process
negative regulation of cytolysis
symbiont-containing vacuole membrane
killing by host of symbiont cells
disruption by host of symbiont cells
killing of cells in other organism involved in symbiotic interaction
disruption of cells of other organism involved in symbiotic interaction
positive regulation of macrophage differentiation
regulation of MHC class II biosynthetic process
positive regulation of macrophage derived foam cell differentiation
regulation of cytolysis
regulation of macrophage differentiation
defense response to protozoan
response to protozoan
regulation of macrophage derived foam cell differentiation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of signal transduction in absence of ligand
regulation of extrinsic apoptotic signaling pathway in absence of ligand
chemokine activity
disruption of cells of other organism
killing of cells of other organism
regulation of megakaryocyte differentiation
positive regulation of myeloid leukocyte differentiation
antimicrobial humoral immune response mediated by antimicrobial peptide
platelet alpha granule lumen
modification by host of symbiont morphology or physiology
negative regulation of myeloid cell differentiation
interaction with symbiont
chemokine-mediated signaling pathway
neutrophil chemotaxis
positive regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor superfamily cytokine production
granulocyte chemotaxis
cell killing
cellular response to chemokine
response to chemokine
positive regulation of myeloid cell differentiation