PFAS [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= PFAS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PFAS
  * **<color #00a2e8>Official Name</color>**: phosphoribosylformylglycinamidine synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5198|5198]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15067|O15067]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PFAS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PFAS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602133|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AIRS|
|AIRS C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphoribosylformylglycinamidine synthase activity|
|anterior head development|
|de novo IMP biosynthetic process|
|IMP biosynthetic process|
|IMP metabolic process|
|purine ribonucleoside monophosphate biosynthetic process|
|purine nucleoside monophosphate biosynthetic process|
|glutamine metabolic process|
|ribonucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|nucleoside monophosphate biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|glutamine family amino acid metabolic process|
|nucleoside monophosphate metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|alpha-amino acid metabolic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|cellular amino acid metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|head development|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-2.2|
|[[:results:exp302|35°C R06 exp302]]|-1.89|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.82|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.73|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.71|
|[[:results:exp539|42°C R08 exp539]]|1.73|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.78|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.92|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.03|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 24/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|4/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 656
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PFAS Expression in NALM6 Cells: 7.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>