PFAS

Entrez Summary: N/A
UniProt Summary: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 24/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	4/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	1/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AIRS
AIRS C

phosphoribosylformylglycinamidine synthase activity
anterior head development
de novo IMP biosynthetic process
IMP biosynthetic process
IMP metabolic process
purine ribonucleoside monophosphate biosynthetic process
purine nucleoside monophosphate biosynthetic process
glutamine metabolic process
ribonucleoside monophosphate biosynthetic process
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
nucleoside monophosphate biosynthetic process
ribonucleoside monophosphate metabolic process
glutamine family amino acid metabolic process
nucleoside monophosphate metabolic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
alpha-amino acid metabolic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
cellular amino acid metabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
head development
organophosphate metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
response to drug
organic acid metabolic process