PFDN6

Entrez Summary: N/A
UniProt Summary: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 672/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	25/28
blood	25/28
bone	23/26
breast	29/33
central nervous system	52/56
cervix	4/4
colorectal	15/17
esophagus	11/13
fibroblast	1/1
gastric	15/16
kidney	16/21
liver	19/20
lung	69/75
lymphocyte	13/16
ovary	25/26
pancreas	24/24
peripheral nervous system	12/16
plasma cell	13/15
prostate	0/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	26/29
uterus	4/5

Expression Distribution

Screen	Score
Phenformin 20μM R03 exp143	-2.07
UNC1999 2μM R03 exp155	-1.75

prefoldin complex
chaperone-mediated protein complex assembly
chaperone binding
unfolded protein binding
protein folding
cellular protein-containing complex assembly
protein-containing complex assembly
protein-containing complex subunit organization