PFKFB1

Gene Information

Official Symbol: PFKFB1
Official Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Aliases and Previous Symbols: N/A
Entrez ID: 5207
UniProt: P16118
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012].
UniProt Summary: Synthesis and degradation of fructose 2,6-bisphosphate.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18742
Expression level (log2 read counts): -0.84

Expression Distribution

6PF2K
His Phos 1

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
6-phosphofructo-2-kinase activity
fructose 2,6-bisphosphate metabolic process
fructose-6-phosphate binding
positive regulation of glucokinase activity
fructose-2,6-bisphosphate 2-phosphatase activity
positive regulation of hexokinase activity
regulation of glucokinase activity
regulation of hexokinase activity
negative regulation of glycolytic process
fructose metabolic process
negative regulation of purine nucleotide metabolic process
negative regulation of nucleotide metabolic process
positive regulation of glycolytic process
carbohydrate phosphorylation
negative regulation of ATP metabolic process
response to glucagon
glycolytic process
ATP generation from ADP
negative regulation of cellular carbohydrate metabolic process
gluconeogenesis
positive regulation of ATP metabolic process
positive regulation of purine nucleotide metabolic process
positive regulation of nucleotide metabolic process
hexose biosynthetic process
negative regulation of carbohydrate metabolic process
ADP metabolic process
monosaccharide biosynthetic process
positive regulation of cellular carbohydrate metabolic process
nucleoside diphosphate phosphorylation
purine ribonucleoside diphosphate metabolic process
nucleotide phosphorylation
purine nucleoside diphosphate metabolic process
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
animal organ regeneration
regulation of glycolytic process
positive regulation of carbohydrate metabolic process
nucleoside diphosphate metabolic process
regulation of carbohydrate catabolic process