PFN3

Entrez Summary: N/A
UniProt Summary: Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis. {ECO:0000269|PubMed:19419568}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of actin filament bundle assembly
regulation of actin filament bundle assembly
lipid binding
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
positive regulation of cytoskeleton organization
regulation of protein polymerization
regulation of actin filament organization
actin binding
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
cytoskeleton
regulation of cellular component size
regulation of actin filament-based process
regulation of protein complex assembly
actin cytoskeleton organization
regulation of anatomical structure size
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
actin filament-based process
positive regulation of organelle organization
regulation of cellular component biogenesis
cytoskeleton organization
positive regulation of cellular component organization
regulation of organelle organization