PGAM1
Gene Information
- Official Symbol: PGAM1
- Official Name: phosphoglycerate mutase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5223
- UniProt: P18669
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
Pfam Domains GO Terms
Pfam Domains
| His Phos 1 |
GO Terms
| regulation of pentose-phosphate shunt |
| phosphoglycerate mutase activity |
| bisphosphoglycerate mutase activity |
| regulation of NADP metabolic process |
| regulation of cellular carbohydrate catabolic process |
| regulation of secondary metabolic process |
| respiratory burst |
| canonical glycolysis |
| glucose catabolic process to pyruvate |
| NADH regeneration |
| glycolytic process through fructose-6-phosphate |
| glycolytic process through glucose-6-phosphate |
| glucose catabolic process |
| NADH metabolic process |
| glycolytic process |
| ATP generation from ADP |
| gluconeogenesis |
| NAD metabolic process |
| hexose biosynthetic process |
| ADP metabolic process |
| hexose catabolic process |
| monosaccharide biosynthetic process |
| nucleoside diphosphate phosphorylation |
| monosaccharide catabolic process |
| purine nucleoside diphosphate metabolic process |
| nucleotide phosphorylation |
| purine ribonucleoside diphosphate metabolic process |
| ribonucleoside diphosphate metabolic process |
| pyruvate metabolic process |
| hydrolase activity |
| regulation of glycolytic process |
| nucleoside diphosphate metabolic process |
| regulation of carbohydrate catabolic process |
| glucose metabolic process |
| secretory granule lumen |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| carbohydrate catabolic process |
| regulation of ATP metabolic process |
| ficolin-1-rich granule lumen |
| carbohydrate biosynthetic process |
| regulation of cellular carbohydrate metabolic process |
| hexose metabolic process |
| regulation of generation of precursor metabolites and energy |
| monosaccharide metabolic process |
| regulation of carbohydrate metabolic process |
| ATP metabolic process |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| purine-containing compound metabolic process |
| regulation of cellular amide metabolic process |
| generation of precursor metabolites and energy |
| regulation of small molecule metabolic process |
| small molecule catabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| protein kinase binding |
| carbohydrate metabolic process |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| monocarboxylic acid metabolic process |
| nucleobase-containing small molecule metabolic process |
| myeloid leukocyte activation |
| small molecule biosynthetic process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulated exocytosis |
| leukocyte mediated immunity |
| exocytosis |
| regulation of cellular catabolic process |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| leukocyte activation |
| oxidation-reduction process |
| regulation of catabolic process |
| oxoacid metabolic process |
| secretion by cell |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| export from cell |
| cell activation |
| immune effector process |
| secretion |
| phosphorylation |
| regulation of phosphorylation |
| small molecule metabolic process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Phenformin 20μM R03 exp143 | -1.75 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 206/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 9/28 |
| blood | 7/28 |
| bone | 10/26 |
| breast | 9/33 |
| central nervous system | 27/56 |
| cervix | 0/4 |
| colorectal | 5/17 |
| esophagus | 4/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 2/21 |
| liver | 7/20 |
| lung | 16/75 |
| lymphocyte | 3/16 |
| ovary | 5/26 |
| pancreas | 5/24 |
| peripheral nervous system | 8/16 |
| plasma cell | 4/15 |
| prostate | 0/1 |
| skin | 9/24 |
| soft tissue | 2/9 |
| thyroid | 1/2 |
| upper aerodigestive | 6/22 |
| urinary tract | 9/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 774
- Expression level (log2 read counts): 7.9
Expression Distribution
PGAM1 Expression in NALM6 Cells: 7.9
