PGAM5 [The Human Chemical-Genetic Interaction Map Project]

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======= PGAM5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PGAM5
  * **<color #00a2e8>Official Name</color>**: PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=192111|192111]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96HS1|Q96HS1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PGAM5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PGAM5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614939|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|His Phos 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|necroptotic process|
|programmed necrotic cell death|
|necrotic cell death|
|phosphatase activity|
|negative regulation of cold-induced thermogenesis|
|protein serine/threonine phosphatase activity|
|regulation of cold-induced thermogenesis|
|macroautophagy|
|mitochondrial outer membrane|
|protein dephosphorylation|
|autophagy|
|process utilizing autophagic mechanism|
|protein-containing complex binding|
|GTPase activator activity|
|dephosphorylation|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|positive regulation of hydrolase activity|
|programmed cell death|
|cell death|
|negative regulation of multicellular organismal process|
|mitochondrion|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|positive regulation of molecular function|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7927
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PGAM5 Expression in NALM6 Cells: 6.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>