PGAM5

Official Symbol: PGAM5
Official Name: PGAM family member 5, mitochondrial serine/threonine protein phosphatase
Aliases and Previous Symbols: N/A
Entrez ID: 192111
UniProt: Q96HS1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution

necroptotic process
programmed necrotic cell death
necrotic cell death
phosphatase activity
negative regulation of cold-induced thermogenesis
protein serine/threonine phosphatase activity
regulation of cold-induced thermogenesis
macroautophagy
mitochondrial outer membrane
protein dephosphorylation
autophagy
process utilizing autophagic mechanism
protein-containing complex binding
GTPase activator activity
dephosphorylation
positive regulation of GTPase activity
regulation of GTPase activity
positive regulation of hydrolase activity
programmed cell death
cell death
negative regulation of multicellular organismal process
mitochondrion
regulation of hydrolase activity
positive regulation of catalytic activity
positive regulation of molecular function
cellular catabolic process