PGF [The Human Chemical-Genetic Interaction Map Project]

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======= PGF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PGF
  * **<color #00a2e8>Official Name</color>**: placental growth factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5228|5228]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49763|P49763]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PGF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PGF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601121|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. {ECO:0000269|PubMed:21215706}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mast cell chemotaxis|
|vascular endothelial growth factor receptor binding|
|regulation of mast cell chemotaxis|
|induction of positive chemotaxis|
|vascular endothelial growth factor signaling pathway|
|positive regulation of positive chemotaxis|
|regulation of positive chemotaxis|
|chemoattractant activity|
|cellular response to vascular endothelial growth factor stimulus|
|branching involved in ureteric bud morphogenesis|
|positive chemotaxis|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of morphogenesis of a branching structure|
|sprouting angiogenesis|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|vascular endothelial growth factor receptor signaling pathway|
|nephron morphogenesis|
|renal tubule morphogenesis|
|animal organ regeneration|
|nephron tubule development|
|renal tubule development|
|kidney morphogenesis|
|ureteric bud development|
|positive regulation of cell division|
|mesonephric tubule development|
|mesonephric epithelium development|
|positive regulation of leukocyte chemotaxis|
|mesonephros development|
|positive regulation of endothelial cell proliferation|
|nephron epithelium development|
|regulation of leukocyte chemotaxis|
|nephron development|
|positive regulation of leukocyte migration|
|regulation of endothelial cell proliferation|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|positive regulation of chemotaxis|
|regeneration|
|morphogenesis of a branching epithelium|
|growth factor activity|
|positive regulation of angiogenesis|
|morphogenesis of a branching structure|
|regulation of cell division|
|heparin binding|
|female pregnancy|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|regulation of leukocyte migration|
|multi-multicellular organism process|
|regulation of chemotaxis|
|kidney development|
|renal system development|
|regulation of angiogenesis|
|epithelial tube morphogenesis|
|angiogenesis|
|urogenital system development|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|blood vessel morphogenesis|
|morphogenesis of an epithelium|
|blood vessel development|
|protein heterodimerization activity|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|tissue morphogenesis|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|tube morphogenesis|
|enzyme linked receptor protein signaling pathway|
|tube development|
|regulation of cell migration|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|locomotion|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.44|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13924
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PGF Expression in NALM6 Cells: 2.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>