PGF

Entrez Summary: This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011].
UniProt Summary: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. {ECO:0000269|PubMed:21215706}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Methotrexate 0.01μM R08 exp501	-2.44
UM0129480 7μM R02 exp85	1.7

positive regulation of mast cell chemotaxis
vascular endothelial growth factor receptor binding
regulation of mast cell chemotaxis
induction of positive chemotaxis
vascular endothelial growth factor signaling pathway
positive regulation of positive chemotaxis
regulation of positive chemotaxis
chemoattractant activity
cellular response to vascular endothelial growth factor stimulus
branching involved in ureteric bud morphogenesis
positive chemotaxis
ureteric bud morphogenesis
mesonephric tubule morphogenesis
regulation of morphogenesis of a branching structure
sprouting angiogenesis
nephron tubule morphogenesis
nephron epithelium morphogenesis
vascular endothelial growth factor receptor signaling pathway
nephron morphogenesis
renal tubule morphogenesis
animal organ regeneration
nephron tubule development
renal tubule development
kidney morphogenesis
ureteric bud development
positive regulation of cell division
mesonephric tubule development
mesonephric epithelium development
positive regulation of leukocyte chemotaxis
mesonephros development
positive regulation of endothelial cell proliferation
nephron epithelium development
regulation of leukocyte chemotaxis
nephron development
positive regulation of leukocyte migration
regulation of endothelial cell proliferation
kidney epithelium development
branching morphogenesis of an epithelial tube
positive regulation of chemotaxis
regeneration