PGM1

Entrez Summary: The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nocodazole 0.1μM R03 exp94	1.76
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	1.9

phosphoglucomutase activity
galactose catabolic process
galactose metabolic process
glycogen catabolic process
glucan catabolic process
glucan biosynthetic process
glycogen biosynthetic process
cellular polysaccharide catabolic process
polysaccharide catabolic process
cellular carbohydrate catabolic process
glycolytic process
ATP generation from ADP
polysaccharide biosynthetic process
gluconeogenesis
cellular polysaccharide biosynthetic process
hexose biosynthetic process
glycogen metabolic process
glucan metabolic process
ADP metabolic process
cellular glucan metabolic process
hexose catabolic process
monosaccharide biosynthetic process
tertiary granule lumen
cellular carbohydrate biosynthetic process
nucleoside diphosphate phosphorylation
monosaccharide catabolic process
purine nucleoside diphosphate metabolic process
nucleotide phosphorylation
purine ribonucleoside diphosphate metabolic process
energy reserve metabolic process
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
nucleoside diphosphate metabolic process
glucose metabolic process
carbohydrate catabolic process
ficolin-1-rich granule lumen
carbohydrate biosynthetic process
hexose metabolic process