PGM3 [The Human Chemical-Genetic Interaction Map Project]

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======= PGM3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PGM3
  * **<color #00a2e8>Official Name</color>**: phosphoglucomutase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5238|5238]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95394|O95394]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PGM3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PGM3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172100|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single nucleotide polymorphism in this gene may play a role in resistance to diabetic nephropathy and neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. {ECO:0000303|PubMed:24589341, ECO:0000303|PubMed:24698316, ECO:0000303|PubMed:24931394}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PGM PMM II|
|PGM PMM IV|
|PGM PMM I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphoacetylglucosamine mutase activity|
|glucose 1-phosphate metabolic process|
|glucosamine metabolic process|
|phosphoglucomutase activity|
|UDP-N-acetylglucosamine biosynthetic process|
|amino sugar biosynthetic process|
|UDP-N-acetylglucosamine metabolic process|
|nucleotide-sugar biosynthetic process|
|glucosamine-containing compound metabolic process|
|nucleotide-sugar metabolic process|
|amino sugar metabolic process|
|protein N-linked glycosylation|
|protein O-linked glycosylation|
|magnesium ion binding|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|cellular component|
|carbohydrate metabolic process|
|nucleobase-containing small molecule metabolic process|
|spermatogenesis|
|hemopoiesis|
|male gamete generation|
|hematopoietic or lymphoid organ development|
|carbohydrate derivative biosynthetic process|
|immune system development|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|organophosphate metabolic process|
|multi-organism reproductive process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-2.36|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.97|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.92|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.92|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.92|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.92|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.87|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.84|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.75|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.74|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.71|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.7|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.72|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.73|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.74|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.75|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.75|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.76|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.79|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.8|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.85|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.88|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.89|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.94|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.99|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.01|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.02|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.03|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.04|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.06|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.07|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.09|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.1|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.13|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.21|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.25|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.36|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.37|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.39|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.43|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.43|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.63|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.69|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.71|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.77|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.81|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|3.01|
|[[:results:exp504|MK2206 4μM R08 exp504]]|3.03|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|3.09|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|3.19|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|3.35|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|3.41|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|3.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dhrsx|DHRSX]]|0.704|
|[[:human genes:p:ppcdc|PPCDC]]|0.636|
|[[:human genes:d:dnlz|DNLZ]]|0.629|
|[[:human genes:p:pmvk|PMVK]]|0.623|
|[[:human genes:s:srd5a3|SRD5A3]]|0.604|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.593|
|[[:human genes:m:mrpl21|MRPL21]]|0.58|
|[[:human genes:t:trmt61a|TRMT61A]]|0.576|
|[[:human genes:s:sco2|SCO2]]|0.576|
|[[:human genes:d:dap3|DAP3]]|0.56|
|[[:human genes:m:mrps6|MRPS6]]|0.559|
|[[:human genes:a:alg6|ALG6]]|0.556|
|[[:human genes:p:pars2|PARS2]]|0.556|
|[[:human genes:l:lsm10|LSM10]]|0.554|
|[[:human genes:n:nars2|NARS2]]|0.549|
|[[:human genes:d:dars2|DARS2]]|0.546|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.545|
|[[:human genes:u:uap1|UAP1]]|0.544|
|[[:human genes:y:yars2|YARS2]]|0.544|
|[[:human genes:t:tars2|TARS2]]|0.544|
|[[:human genes:s:selrc1|SELRC1]]|0.543|
|[[:human genes:f:fastkd5|FASTKD5]]|0.543|
|[[:human genes:b:bcs1l|BCS1L]]|0.542|
|[[:human genes:m:mrps16|MRPS16]]|0.539|
|[[:human genes:f:fh|FH]]|0.531|
|[[:human genes:m:mrpl23|MRPL23]]|0.53|
|[[:human genes:r:romo1|ROMO1]]|0.53|
|[[:human genes:r:rpia|RPIA]]|0.526|
|[[:human genes:k:kdsr|KDSR]]|0.522|
|[[:human genes:r:rbfa|RBFA]]|0.521|
|[[:human genes:t:triap1|TRIAP1]]|0.52|
|[[:human genes:m:mrps34|MRPS34]]|0.518|
|[[:human genes:r:rft1|RFT1]]|0.516|
|[[:human genes:g:gfm1|GFM1]]|0.515|
|[[:human genes:d:dolk|DOLK]]|0.513|
|[[:human genes:p:ppa2|PPA2]]|0.511|
|[[:human genes:m:mrps14|MRPS14]]|0.51|
|[[:human genes:e:ears2|EARS2]]|0.509|
|[[:human genes:c:c10orf2|C10orf2]]|0.509|
|[[:human genes:a:atic|ATIC]]|0.509|
|[[:human genes:m:mrps5|MRPS5]]|0.508|
|[[:human genes:r:rpusd4|RPUSD4]]|0.503|
|[[:human genes:t:tmem242|TMEM242]]|0.502|
|[[:human genes:v:vars2|VARS2]]|0.501|
|[[:human genes:m:mrps2|MRPS2]]|0.499|
|[[:human genes:a:aars2|AARS2]]|0.499|
|[[:human genes:p:ppcs|PPCS]]|0.498|
|[[:human genes:s:slc25a26|SLC25A26]]|0.494|
|[[:human genes:t:ten1|TEN1]]|0.493|
|[[:human genes:c:coa3|COA3]]|0.491|
|[[:human genes:m:mrpl47|MRPL47]]|0.489|
|[[:human genes:s:srp14|SRP14]]|0.487|
|[[:human genes:q:qrsl1|QRSL1]]|0.486|
|[[:human genes:r:rars2|RARS2]]|0.485|
|[[:human genes:t:tamm41|TAMM41]]|0.485|
|[[:human genes:m:mbtps2|MBTPS2]]|0.484|
|[[:human genes:p:ptar1|PTAR1]]|0.483|
|[[:human genes:t:thg1l|THG1L]]|0.482|
|[[:human genes:m:mrps18a|MRPS18A]]|0.481|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.481|
|[[:human genes:g:gatc|GATC]]|0.481|
|[[:human genes:p:polg|POLG]]|0.48|
|[[:human genes:t:tkt|TKT]]|0.479|
|[[:human genes:m:mrps21|MRPS21]]|0.478|
|[[:human genes:c:c15orf41|C15orf41]]|0.476|
|[[:human genes:r:rpe|RPE]]|0.475|
|[[:human genes:l:lars2|LARS2]]|0.473|
|[[:human genes:a:atp5a1|ATP5A1]]|0.47|
|[[:human genes:g:gemin7|GEMIN7]]|0.468|
|[[:human genes:h:hccs|HCCS]]|0.465|
|[[:human genes:t:tpk1|TPK1]]|0.465|
|[[:human genes:a:alg8|ALG8]]|0.465|
|[[:human genes:p:pmm2|PMM2]]|0.464|
|[[:human genes:s:ssb|SSB]]|0.463|
|[[:human genes:s:sec62|SEC62]]|0.463|
|[[:human genes:a:atxn10|ATXN10]]|0.461|
|[[:human genes:g:gemin6|GEMIN6]]|0.46|
|[[:human genes:d:dpagt1|DPAGT1]]|0.459|
|[[:human genes:h:hars2|HARS2]]|0.459|
|[[:human genes:s:sars2|SARS2]]|0.458|
|[[:human genes:a:alg1|ALG1]]|0.457|
|[[:human genes:p:ppp6c|PPP6C]]|0.457|
|[[:human genes:i:iba57|IBA57]]|0.455|
|[[:human genes:g:gfm2|GFM2]]|0.455|
|[[:human genes:m:mtg2|MTG2]]|0.454|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.45|
|[[:human genes:m:mrps9|MRPS9]]|0.449|
|[[:human genes:m:mrpl15|MRPL15]]|0.449|
|[[:human genes:e:elp6|ELP6]]|0.448|
|[[:human genes:e:elp3|ELP3]]|0.448|
|[[:human genes:a:atp5c1|ATP5C1]]|0.448|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.447|
|[[:human genes:c:cxorf56|CXorf56]]|0.446|
|[[:human genes:m:mettl1|METTL1]]|0.446|
|[[:human genes:u:uqcc2|UQCC2]]|0.445|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.445|
|[[:human genes:v:vezt|VEZT]]|0.444|
|[[:human genes:c:crls1|CRLS1]]|0.444|
|[[:human genes:u:ugp2|UGP2]]|0.443|
|[[:human genes:t:tufm|TUFM]]|0.443|
|[[:human genes:u:uso1|USO1]]|0.443|
|[[:human genes:p:polrmt|POLRMT]]|0.443|
|[[:human genes:m:mrpl53|MRPL53]]|0.442|
|[[:human genes:g:gemin8|GEMIN8]]|0.441|
|[[:human genes:z:znhit1|ZNHIT1]]|0.44|
|[[:human genes:a:atp5j|ATP5J]]|0.439|
|[[:human genes:c:cox16|COX16]]|0.439|
|[[:human genes:p:ptdss1|PTDSS1]]|0.438|
|[[:human genes:m:mrp63|MRP63]]|0.438|
|[[:human genes:m:msto1|MSTO1]]|0.437|
|[[:human genes:g:gnpnat1|GNPNAT1]]|0.436|
|[[:human genes:r:rabggtb|RABGGTB]]|0.434|
|[[:human genes:m:mars2|MARS2]]|0.434|
|[[:human genes:c:cep57|CEP57]]|0.433|
|[[:human genes:w:wbscr16|WBSCR16]]|0.432|
|[[:human genes:u:urm1|URM1]]|0.432|
|[[:human genes:c:cept1|CEPT1]]|0.431|
|[[:human genes:c:ctu1|CTU1]]|0.431|
|[[:human genes:o:opa1|OPA1]]|0.43|
|[[:human genes:t:trmt6|TRMT6]]|0.43|
|[[:human genes:d:ddx39a|DDX39A]]|0.43|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.427|
|[[:human genes:g:g6pd|G6PD]]|0.427|
|[[:human genes:n:nbn|NBN]]|0.427|
|[[:human genes:p:pgs1|PGS1]]|0.427|
|[[:human genes:p:pdss1|PDSS1]]|0.426|
|[[:human genes:c:chchd4|CHCHD4]]|0.425|
|[[:human genes:n:n6amt1|N6AMT1]]|0.425|
|[[:human genes:c:c17orf89|C17orf89]]|0.425|
|[[:human genes:p:prkrip1|PRKRIP1]]|0.422|
|[[:human genes:a:adat2|ADAT2]]|0.421|
|[[:human genes:w:wrb|WRB]]|0.421|
|[[:human genes:m:mrps26|MRPS26]]|0.421|
|[[:human genes:c:c12orf65|C12orf65]]|0.421|
|[[:human genes:r:rpp21|RPP21]]|0.42|
|[[:human genes:p:ppa1|PPA1]]|0.42|
|[[:human genes:n:ndufb1|NDUFB1]]|0.418|
|[[:human genes:t:tsen15|TSEN15]]|0.416|
|[[:human genes:m:mrps11|MRPS11]]|0.415|
|[[:human genes:d:dohh|DOHH]]|0.415|
|[[:human genes:e:elp2|ELP2]]|0.415|
|[[:human genes:m:mocs3|MOCS3]]|0.413|
|[[:human genes:g:gfpt1|GFPT1]]|0.413|
|[[:human genes:h:h2afz|H2AFZ]]|0.412|
|[[:human genes:m:mipep|MIPEP]]|0.411|
|[[:human genes:a:atp5sl|ATP5SL]]|0.41|
|[[:human genes:a:adsl|ADSL]]|0.41|
|[[:human genes:m:mbtps1|MBTPS1]]|0.408|
|[[:human genes:t:taz|TAZ]]|0.408|
|[[:human genes:c:cycs|CYCS]]|0.407|
|[[:human genes:p:polg2|POLG2]]|0.405|
|[[:human genes:s:slc25a52|SLC25A52]]|0.404|
|[[:human genes:m:mrpl42|MRPL42]]|0.404|
|[[:human genes:c:cox11|COX11]]|0.404|
|[[:human genes:f:fkbpl|FKBPL]]|0.403|
|[[:human genes:a:atp5o|ATP5O]]|0.403|
|[[:human genes:c:coq3|COQ3]]|0.402|
|[[:human genes:p:psmg2|PSMG2]]|0.402|
|[[:human genes:m:mrpl12|MRPL12]]|0.402|
|[[:human genes:w:wars2|WARS2]]|0.402|
|[[:human genes:h:hspa14|HSPA14]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 16/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2309
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PGM3 Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>