PGM3

Gene Information

Official Symbol: PGM3
Official Name: phosphoglucomutase 3
Aliases and Previous Symbols: N/A
Entrez ID: 5238
UniProt: O95394
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single nucleotide polymorphism in this gene may play a role in resistance to diabetic nephropathy and neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
UniProt Summary: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. {ECO:0000303|PubMed:24589341, ECO:0000303|PubMed:24698316, ECO:0000303|PubMed:24931394}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SGC2043 10μM R03 exp152	-2.36
SGC0946 7μM R03 exp151	-1.97
Hypoxia 5%O2 R04 exp191	-1.92
BS-181 20μM R08 exp461	-1.92
Dynasore 10μM R04 exp180	-1.92
Ethanol 0.01 R05 exp234	-1.92
NFN1 1μM R03 exp100	-1.87
TNF-alpha 44ng/ml R08 exp533	-1.84
A-366 10μM R03 exp115	-1.75
SGC2096 2.6μM R03 exp153	-1.74
Lenalidomide 20μM R07 exp375	-1.71
Phenformin 20μM R05 exp212	1.7
Staurosporine 0.02μM R08 exp524	1.72
Tozasertib 0.1μM R07 exp414	1.73
Artemisinin 50μM R08 exp450	1.74
CAY10603 0.55μM R08 exp467	1.75
Quercetin 20μM R08 exp517	1.75
Bisphenol A 100μM R06 exp269	1.76
5-Azacytidine 2μM R07 exp330	1.79
BI-D1870 2μM R04 exp162	1.8
Hydroxyurea 100μM R07 exp329	1.85
Senexin-A 25μM R07 exp400	1.88
Cryptotanshinone 12μM R05 exp227	1.89
HMS-I1 10μM R06 exp256	1.94
Arsenic trioxide 60μM R08 exp449	1.99
THZ1 0.06μM R08 exp531	2.01
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.02
Deferoxamine 11μM R07 exp350	2.03
Dinaciclib 0.007μM R07 exp355	2.04
TIC10 10μM R08 exp532	2.06
CI-1040 9.5μM R08 exp472	2.07
Actinomycin-D 0.001μM R00 exp3	2.09
Erlotinib 10μM R05 exp216	2.1
Arsenate 40μM R06 exp264	2.13
Amiloride 100μM R08 exp447	2.21
I-BRD9 4μM R07 exp365	2.25
Ammonium tetrathiomolybdate 10μM R08 exp448	2.36
GSK-J4 1.5μM R08 exp441	2.37
Doxorubicin 0.02μM R08 exp478	2.39
INK128 0.2μM R02 exp70	2.43
Milciclib 2μM R08 exp502	2.43
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.63
Rapamycin 2μM R07 exp306	2.69
GSK626616 14μM R08 exp485	2.71
iCRT14 30μM R08 exp492	2.77
Hippuristanol 0.12μM R08 exp488	2.81
Rotenone 0.07μM R08 exp431	3.01
MK2206 4μM R08 exp504	3.03
Torin1 0.08μM R02 exp82	3.09
Mubritinib 0.2μM R02 exp65	3.19
Mubritinib 0.2μM R01 exp48	3.35
CoCl2 18μM R07 exp346	3.41
BI-D1870 3.15μM R02 exp66	3.42

Gene	Correlation
DHRSX	0.704
PPCDC	0.636
DNLZ	0.629
PMVK	0.623
SRD5A3	0.604
HSD17B10	0.593
MRPL21	0.58
TRMT61A	0.576
SCO2	0.576
DAP3	0.56
MRPS6	0.559
ALG6	0.556
PARS2	0.556
LSM10	0.554
NARS2	0.549
DARS2	0.546
PTPMT1	0.545
UAP1	0.544
YARS2	0.544
TARS2	0.544
SELRC1	0.543
FASTKD5	0.543
BCS1L	0.542
MRPS16	0.539
FH	0.531
MRPL23	0.53
ROMO1	0.53
RPIA	0.526
KDSR	0.522
RBFA	0.521
TRIAP1	0.52
MRPS34	0.518
RFT1	0.516
GFM1	0.515
DOLK	0.513
PPA2	0.511
MRPS14	0.51
EARS2	0.509
C10orf2	0.509
ATIC	0.509
MRPS5	0.508
RPUSD4	0.503
TMEM242	0.502
VARS2	0.501
MRPS2	0.499
AARS2	0.499
PPCS	0.498
SLC25A26	0.494
TEN1	0.493
COA3	0.491
MRPL47	0.489
SRP14	0.487
QRSL1	0.486
RARS2	0.485
TAMM41	0.485
MBTPS2	0.484
PTAR1	0.483
THG1L	0.482
MRPS18A	0.481
KIAA0391	0.481
GATC	0.481
POLG	0.48
TKT	0.479
MRPS21	0.478
C15orf41	0.476
RPE	0.475
LARS2	0.473
ATP5A1	0.47
GEMIN7	0.468
HCCS	0.465
TPK1	0.465
ALG8	0.465
PMM2	0.464
SSB	0.463
SEC62	0.463
ATXN10	0.461
GEMIN6	0.46
DPAGT1	0.459
HARS2	0.459
SARS2	0.458
ALG1	0.457
PPP6C	0.457
IBA57	0.455
GFM2	0.455
MTG2	0.454
RNASEH1	0.45
MRPS9	0.449
MRPL15	0.449
ELP6	0.448
ELP3	0.448
ATP5C1	0.448
AASDHPPT	0.447
CXorf56	0.446
METTL1	0.446
UQCC2	0.445
GTPBP10	0.445
VEZT	0.444
CRLS1	0.444
UGP2	0.443
TUFM	0.443
USO1	0.443
POLRMT	0.443
MRPL53	0.442
GEMIN8	0.441
ZNHIT1	0.44
ATP5J	0.439
COX16	0.439
PTDSS1	0.438
MRP63	0.438
MSTO1	0.437
GNPNAT1	0.436
RABGGTB	0.434
MARS2	0.434
CEP57	0.433
WBSCR16	0.432
URM1	0.432
CEPT1	0.431
CTU1	0.431
OPA1	0.43
TRMT6	0.43
DDX39A	0.43
SUPV3L1	0.427
G6PD	0.427
NBN	0.427
PGS1	0.427
PDSS1	0.426
CHCHD4	0.425
N6AMT1	0.425
C17orf89	0.425
PRKRIP1	0.422
ADAT2	0.421
WRB	0.421
MRPS26	0.421
C12orf65	0.421
RPP21	0.42
PPA1	0.42
NDUFB1	0.418
TSEN15	0.416
MRPS11	0.415
DOHH	0.415
ELP2	0.415
MOCS3	0.413
GFPT1	0.413
H2AFZ	0.412
MIPEP	0.411
ATP5SL	0.41
ADSL	0.41
MBTPS1	0.408
TAZ	0.408
CYCS	0.407
POLG2	0.405
SLC25A52	0.404
MRPL42	0.404
COX11	0.404
FKBPL	0.403
ATP5O	0.403
COQ3	0.402
PSMG2	0.402
MRPL12	0.402
WARS2	0.402
HSPA14	0.401

Global Fraction of Cell Lines Where Essential: 16/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2309
Expression level (log2 read counts): 5.68

Expression Distribution

PGM PMM II
PGM PMM IV
PGM PMM I

phosphoacetylglucosamine mutase activity
glucose 1-phosphate metabolic process
glucosamine metabolic process
phosphoglucomutase activity
UDP-N-acetylglucosamine biosynthetic process
amino sugar biosynthetic process
UDP-N-acetylglucosamine metabolic process
nucleotide-sugar biosynthetic process
glucosamine-containing compound metabolic process
nucleotide-sugar metabolic process
amino sugar metabolic process
protein N-linked glycosylation
protein O-linked glycosylation
magnesium ion binding
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
cellular component
carbohydrate metabolic process
nucleobase-containing small molecule metabolic process
spermatogenesis
hemopoiesis
male gamete generation
hematopoietic or lymphoid organ development
carbohydrate derivative biosynthetic process
immune system development
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
organophosphate metabolic process
multi-organism reproductive process
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process