HSPA14

Entrez Summary: N/A
UniProt Summary: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity. {ECO:0000269|PubMed:16002468}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Olaparib 4μM R08 exp512	-2.17
GSK626616 14μM R08 exp485	-2.03
Artemisinin 50μM R08 exp450	1.72
FK-506 30μM R07 exp359	1.74
Thapsigargin 0.005μM R07 exp407	1.78
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.83
CB-5083 0.4μM R08 exp468	1.84
Cytochalasin-B 5μM R07 exp349	1.86
Oligomycin-A 2μM R00 exp25	1.86
BI-6727 0.04μM R03 exp98	1.98
Rapamycin 0.001μM R08 exp429	2.09
Hippuristanol 0.12μM R08 exp488	2.22
BI-6727 0.0125μM R03 exp97	2.23
Latrunculin-B 10μM R07 exp374	2.42
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.57
Arsenic trioxide 60μM R08 exp449	3.25
BI-2536 0.0042μM R03 exp95	3.39
Arsenate 40μM R06 exp264	3.62
MK2206 4μM R08 exp504	4.6

Global Fraction of Cell Lines Where Essential: 46/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	1/26
breast	0/33
central nervous system	4/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	1/16
kidney	5/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	2/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	7/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	4/29
uterus	0/5

Expression Distribution

MreB Mbl
HSP70

de novo cotranslational protein folding
ATPase activity, coupled
regulation of translational fidelity
protein folding chaperone
misfolded protein binding
chaperone cofactor-dependent protein refolding
protein refolding
de novo posttranslational protein folding
de novo protein folding
polysome
ribosome
chaperone-mediated protein folding
heat shock protein binding
cellular response to heat
cytoplasmic translation
response to heat
cellular response to unfolded protein
unfolded protein binding
cellular response to topologically incorrect protein
response to unfolded protein
response to temperature stimulus
response to topologically incorrect protein
protein folding
ATPase activity
translation
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
response to abiotic stimulus
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane
gene expression