PHB [The Human Chemical-Genetic Interaction Map Project]

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======= PHB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHB
  * **<color #00a2e8>Official Name</color>**: prohibitin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5245|5245]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35232|P35232]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. {ECO:0000269|PubMed:11302691}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Band 7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|complement component C3a binding|
|proteinase activated receptor binding|
|positive regulation of complement activation|
|complement component C3b binding|
|negative regulation of glucocorticoid receptor signaling pathway|
|progesterone receptor signaling pathway|
|regulation of glucocorticoid receptor signaling pathway|
|negative regulation of transcription by competitive promoter binding|
|negative regulation of androgen receptor signaling pathway|
|positive regulation of humoral immune response|
|mitochondrial calcium ion transmembrane transport|
|regulation of androgen receptor signaling pathway|
|positive regulation of G protein-coupled receptor signaling pathway|
|cellular response to interleukin-6|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|response to interleukin-6|
|histone deacetylation|
|protein deacetylation|
|protein deacylation|
|macromolecule deacylation|
|negative regulation of ERK1 and ERK2 cascade|
|intracellular steroid hormone receptor signaling pathway|
|regulation of intracellular steroid hormone receptor signaling pathway|
|DNA biosynthetic process|
|histone deacetylase binding|
|regulation of complement activation|
|steroid hormone mediated signaling pathway|
|osteoblast differentiation|
|negative regulation of protein catabolic process|
|regulation of humoral immune response|
|regulation of G protein-coupled receptor signaling pathway|
|intracellular receptor signaling pathway|
|negative regulation of MAPK cascade|
|hormone-mediated signaling pathway|
|protein stabilization|
|negative regulation of cell growth|
|cellular response to steroid hormone stimulus|
|protein C-terminus binding|
|calcium ion transmembrane transport|
|positive regulation of ERK1 and ERK2 cascade|
|transcription regulatory region DNA binding|
|positive regulation of immune effector process|
|negative regulation of growth|
|calcium ion transport|
|early endosome|
|ossification|
|regulation of protein stability|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|divalent inorganic cation transport|
|negative regulation of catabolic process|
|response to steroid hormone|
|enzyme binding|
|histone modification|
|covalent chromatin modification|
|regulation of protein catabolic process|
|mitochondrial inner membrane|
|negative regulation of protein phosphorylation|
|regulation of cell growth|
|mitochondrion organization|
|negative regulation of phosphorylation|
|regulation of immune effector process|
|negative regulation of intracellular signal transduction|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|negative regulation of phosphate metabolic process|
|inorganic cation transmembrane transport|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of growth|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|chromatin organization|
|DNA metabolic process|
|regulation of MAPK cascade|
|cation transport|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|response to hormone|
|response to organic cyclic compound|
|ion transmembrane transport|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of signal transduction|
|transmembrane transport|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.74|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.81|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.82|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.83|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.88|
|[[:results:exp539|42°C R08 exp539]]|2.03|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.43|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rnmt|RNMT]]|0.494|
|[[:human genes:t:triap1|TRIAP1]]|0.455|
|[[:human genes:p:pelo|PELO]]|0.45|
|[[:human genes:d:dpagt1|DPAGT1]]|0.439|
|[[:human genes:h:hccs|HCCS]]|0.43|
|[[:human genes:r:rptor|RPTOR]]|0.428|
|[[:human genes:t:thg1l|THG1L]]|0.427|
|[[:human genes:n:nae1|NAE1]]|0.424|
|[[:human genes:g:gmppb|GMPPB]]|0.418|
|[[:human genes:a:alg1|ALG1]]|0.418|
|[[:human genes:t:timm22|TIMM22]]|0.415|
|[[:human genes:m:med16|MED16]]|0.414|
|[[:human genes:d:dohh|DOHH]]|0.414|
|[[:human genes:p:pmm2|PMM2]]|0.413|
|[[:human genes:h:hspd1|HSPD1]]|0.412|
|[[:human genes:h:hars|HARS]]|0.411|
|[[:human genes:p:plaa|PLAA]]|0.406|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.404|
|[[:human genes:p:pam16|PAM16]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 673/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|27/28|
|blood|27/28|
|bone|22/25|
|breast|28/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|13/15|
|kidney|20/21|
|liver|19/20|
|lung|72/75|
|lymphocyte|11/14|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|13/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 318
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHB Expression in NALM6 Cells: 7.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>