PHB
Gene Information
- Official Symbol: PHB
- Official Name: prohibitin
- Aliases and Previous Symbols: N/A
- Entrez ID: 5245
- UniProt: P35232
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
- UniProt Summary: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. {ECO:0000269|PubMed:11302691}.
Pfam Domains GO Terms
Pfam Domains
| Band 7 |
GO Terms
| complement component C3a binding |
| proteinase activated receptor binding |
| positive regulation of complement activation |
| complement component C3b binding |
| negative regulation of glucocorticoid receptor signaling pathway |
| progesterone receptor signaling pathway |
| regulation of glucocorticoid receptor signaling pathway |
| negative regulation of transcription by competitive promoter binding |
| negative regulation of androgen receptor signaling pathway |
| positive regulation of humoral immune response |
| mitochondrial calcium ion transmembrane transport |
| regulation of androgen receptor signaling pathway |
| positive regulation of G protein-coupled receptor signaling pathway |
| cellular response to interleukin-6 |
| negative regulation of intracellular steroid hormone receptor signaling pathway |
| response to interleukin-6 |
| histone deacetylation |
| protein deacetylation |
| protein deacylation |
| macromolecule deacylation |
| negative regulation of ERK1 and ERK2 cascade |
| intracellular steroid hormone receptor signaling pathway |
| regulation of intracellular steroid hormone receptor signaling pathway |
| DNA biosynthetic process |
| histone deacetylase binding |
| regulation of complement activation |
| steroid hormone mediated signaling pathway |
| osteoblast differentiation |
| negative regulation of protein catabolic process |
| regulation of humoral immune response |
| regulation of G protein-coupled receptor signaling pathway |
| intracellular receptor signaling pathway |
| negative regulation of MAPK cascade |
| hormone-mediated signaling pathway |
| protein stabilization |
| negative regulation of cell growth |
| cellular response to steroid hormone stimulus |
| protein C-terminus binding |
| calcium ion transmembrane transport |
| positive regulation of ERK1 and ERK2 cascade |
| transcription regulatory region DNA binding |
| positive regulation of immune effector process |
| negative regulation of growth |
| calcium ion transport |
| early endosome |
| ossification |
| regulation of protein stability |
| regulation of ERK1 and ERK2 cascade |
| divalent metal ion transport |
| divalent inorganic cation transport |
| negative regulation of catabolic process |
| response to steroid hormone |
| enzyme binding |
| histone modification |
| covalent chromatin modification |
| regulation of protein catabolic process |
| mitochondrial inner membrane |
| negative regulation of protein phosphorylation |
| regulation of cell growth |
| mitochondrion organization |
| negative regulation of phosphorylation |
| regulation of immune effector process |
| negative regulation of intracellular signal transduction |
| cellular response to lipid |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| negative regulation of phosphate metabolic process |
| inorganic cation transmembrane transport |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| cellular response to hormone stimulus |
| cation transmembrane transport |
| cell surface |
| metal ion transport |
| inorganic ion transmembrane transport |
| regulation of growth |
| negative regulation of cell population proliferation |
| positive regulation of cell death |
| chromatin organization |
| DNA metabolic process |
| regulation of MAPK cascade |
| cation transport |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of immune response |
| response to hormone |
| response to organic cyclic compound |
| ion transmembrane transport |
| regulation of catabolic process |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| negative regulation of protein metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| mitochondrion |
| negative regulation of signal transduction |
| transmembrane transport |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| negative regulation of cellular macromolecule biosynthetic process |
| integral component of plasma membrane |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Phenformin 20μM R05 exp212 | 1.74 |
| SB743921 0.001μM R05 exp244 | 1.81 |
| Actinomycin-D 0.001μM R00 exp3 | 1.82 |
| LLY-283 2.6μM R06 exp290 | 1.83 |
| QNZ 0.01μM R08 exp439 | 1.88 |
| 42°C R08 exp539 | 2.03 |
| Vinblastine 0.015μM R05 exp208 | 2.43 |
| Etoposide 0.3μM R05 exp199 | 2.7 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 673/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 27/28 |
| blood | 27/28 |
| bone | 22/25 |
| breast | 28/33 |
| central nervous system | 53/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 13/15 |
| kidney | 20/21 |
| liver | 19/20 |
| lung | 72/75 |
| lymphocyte | 11/14 |
| ovary | 25/26 |
| pancreas | 23/24 |
| peripheral nervous system | 13/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 19/24 |
| soft tissue | 7/7 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 27/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 318
- Expression level (log2 read counts): 7.18
Expression Distribution
PHB Expression in NALM6 Cells: 7.18
