PHF20 [The Human Chemical-Genetic Interaction Map Project]

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======= PHF20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHF20
  * **<color #00a2e8>Official Name</color>**: PHD finger protein 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51230|51230]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVI0|Q9BVI0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHF20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHF20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610335|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3776|
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone acetyltransferase activity (H4-K16 specific)|
|histone acetyltransferase activity (H4-K8 specific)|
|histone acetyltransferase activity (H4-K5 specific)|
|histone H4-K8 acetylation|
|histone H4-K5 acetylation|
|histone H4-K16 acetylation|
|histone acetyltransferase complex|
|MLL1 complex|
|histone H4 acetylation|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|regulation of signal transduction by p53 class mediator|
|protein acylation|
|nuclear membrane|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.13|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.85|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.76|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.79|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.8|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.8|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.8|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.84|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.84|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.85|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.89|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.92|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.95|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.96|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.99|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.17|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.24|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.24|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.33|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.45|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.51|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.61|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.92|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:h2afz|H2AFZ]]|0.491|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1158
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHF20 Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>