PHF20

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.13
Vemurafenib 6.6μM R08 exp434	-1.85
Pyronaridine 1μM R06 exp295	1.76
Nutlin-3A 1.6μM R06 exp294	1.79
Aphidicolin 0.4μM R08 exp440	1.8
FK-506 30μM R07 exp359	1.8
TRAIL 5ng/ml R00 exp35	1.8
LB-100 4.1μM R02 exp72	1.84
SB203580 25μM R03 exp149	1.84
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.85
Cerivastatin 0.15μM R05 exp226	1.89
Thimerosal 0.85μM R08 exp529	1.92
All-trans-Retinoic-Acid 40μM R07 exp334	1.95
Ribavirin 10μM R01 exp52	1.96
Erlotinib 10μM R05 exp216	1.99
Fluvastatin 2.2μM R06 exp282	2.17
Radicicol 0.16μM R05 exp242	2.24
Tozasertib 0.1μM R07 exp414	2.24
Thapsigargin 0.005μM R07 exp407	2.33
Cytochalasin-B 5μM R07 exp349	2.45
Trimetrexate 0.03μM R08 exp535	2.51
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.61
Latrunculin-B 10μM R07 exp374	2.92
Hippuristanol 0.12μM R08 exp488	3.02

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DUF3776
PHD

histone acetyltransferase activity (H4-K16 specific)
histone acetyltransferase activity (H4-K8 specific)
histone acetyltransferase activity (H4-K5 specific)
histone H4-K8 acetylation
histone H4-K5 acetylation
histone H4-K16 acetylation
histone acetyltransferase complex
MLL1 complex
histone H4 acetylation
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
regulation of signal transduction by p53 class mediator
protein acylation
nuclear membrane
peptidyl-lysine modification
histone modification
covalent chromatin modification
chromatin organization
peptidyl-amino acid modification
chromosome organization
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of intracellular signal transduction