PHF23

Entrez Summary: N/A
UniProt Summary: Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. {ECO:0000269|PubMed:25484098}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of autophagosome maturation
regulation of autophagosome maturation
negative regulation of autophagosome assembly
mitotic chromosome condensation
negative regulation of macroautophagy
regulation of autophagosome assembly
negative regulation of organelle assembly
regulation of vacuole organization
chromosome condensation
negative regulation of protein complex disassembly
negative regulation of autophagy
mitotic sister chromatid segregation
regulation of protein complex disassembly
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
sister chromatid segregation
mitotic nuclear division
regulation of macroautophagy
DNA packaging
regulation of protein ubiquitination
nuclear chromosome segregation
regulation of organelle assembly
regulation of protein modification by small protein conjugation or removal
negative regulation of cellular catabolic process
autophagy
process utilizing autophagic mechanism
chromosome segregation
nuclear division
DNA conformation change
negative regulation of catabolic process
organelle fission
regulation of autophagy
negative regulation of organelle organization
chromatin binding
mitotic cell cycle process
mitotic cell cycle
negative regulation of cellular component organization
regulation of cellular catabolic process
regulation of cellular component biogenesis
regulation of catabolic process