PHF2 [The Human Chemical-Genetic Interaction Map Project]

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======= PHF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHF2
  * **<color #00a2e8>Official Name</color>**: PHD finger protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5253|5253]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75151|O75151]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604351|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. {ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|JmjC|
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of chromatin silencing at rDNA|
|regulation of chromatin silencing at rDNA|
|histone demethylase activity (H3-K9 specific)|
|histone H3-K9 demethylation|
|histone demethylase activity|
|negative regulation of chromatin silencing|
|dioxygenase activity|
|histone lysine demethylation|
|histone demethylation|
|protein demethylation|
|protein dealkylation|
|negative regulation of gene silencing|
|regulation of chromatin silencing|
|methylated histone binding|
|negative regulation of chromatin organization|
|positive regulation of gene expression, epigenetic|
|demethylation|
|kinetochore|
|condensed chromosome kinetochore|
|liver development|
|regulation of gene silencing|
|hepaticobiliary system development|
|iron ion binding|
|negative regulation of chromosome organization|
|regulation of chromatin organization|
|regulation of gene expression, epigenetic|
|transcription coactivator activity|
|regulation of chromosome organization|
|histone modification|
|negative regulation of organelle organization|
|covalent chromatin modification|
|gland development|
|chromatin organization|
|negative regulation of cellular component organization|
|zinc ion binding|
|nucleolus|
|oxidation-reduction process|
|chromosome organization|
|regulation of organelle organization|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.73|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.73|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.77|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.8|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.85|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.04|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.08|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:copg1|COPG1]]|0.489|
|[[:human genes:t:tceb3c|TCEB3C]]|0.484|
|[[:human genes:p:polr2j3|POLR2J3]]|0.483|
|[[:human genes:p:psmb2|PSMB2]]|0.475|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.475|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.464|
|[[:human genes:o:orc6|ORC6]]|0.458|
|[[:human genes:a:aqr|AQR]]|0.453|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.443|
|[[:human genes:c:ccna2|CCNA2]]|0.435|
|[[:human genes:a:adra1d|ADRA1D]]|0.428|
|[[:human genes:c:chaf1a|CHAF1A]]|0.428|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.423|
|[[:human genes:b:bysl|BYSL]]|0.421|
|[[:human genes:n:npipb5|NPIPB5]]|0.418|
|[[:human genes:p:prim1|PRIM1]]|0.418|
|[[:human genes:t:tyms|TYMS]]|0.415|
|[[:human genes:c:c14orf93|C14orf93]]|0.415|
|[[:human genes:m:mt1e|MT1E]]|0.41|
|[[:human genes:s:slc4a1|SLC4A1]]|0.409|
|[[:human genes:i:ints5|INTS5]]|0.407|
|[[:human genes:d:dtl|DTL]]|0.407|
|[[:human genes:s:snrpa1|SNRPA1]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2442
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHF2 Expression in NALM6 Cells: 4.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>