PHKG1

Entrez Summary: N/A
UniProt Summary: Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

phosphorylase kinase complex
phosphorylase kinase activity
glycogen catabolic process
glucan catabolic process
glycogen biosynthetic process
glucan biosynthetic process
cellular polysaccharide catabolic process
tau-protein kinase activity
polysaccharide catabolic process
calmodulin-dependent protein kinase activity
cellular carbohydrate catabolic process
cellular polysaccharide biosynthetic process
polysaccharide biosynthetic process
glycogen metabolic process
cellular glucan metabolic process
glucan metabolic process
cellular carbohydrate biosynthetic process
energy reserve metabolic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
carbohydrate catabolic process
carbohydrate biosynthetic process
cellular carbohydrate metabolic process
calmodulin binding
energy derivation by oxidation of organic compounds
enzyme binding
generation of precursor metabolites and energy
carbohydrate metabolic process
oxidation-reduction process
protein phosphorylation
macromolecule catabolic process
phosphorylation
ATP binding
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
organic substance catabolic process
cellular catabolic process