PHLDA2

Entrez Summary: This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010].
UniProt Summary: Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of spongiotrophoblast cell proliferation
regulation of cell proliferation involved in embryonic placenta development
regulation of growth hormone activity
regulation of receptor binding
regulation of glycogen metabolic process
regulation of polysaccharide metabolic process
regulation of glucose metabolic process
regulation of embryonic development
regulation of cellular carbohydrate metabolic process
placenta development
regulation of generation of precursor metabolites and energy
regulation of reproductive process
regulation of signaling receptor activity
regulation of carbohydrate metabolic process
regulation of protein binding
regulation of developmental growth
regulation of binding
reproductive structure development
regulation of small molecule metabolic process
reproductive system development
developmental process involved in reproduction
regulation of growth
regulation of cell migration
regulation of cell motility
apoptotic process
animal organ morphogenesis
regulation of locomotion
regulation of cellular component movement
programmed cell death
cell death
reproductive process
reproduction
regulation of cell population proliferation
membrane