PHLDB2

Gene Information

Official Symbol: PHLDB2
Official Name: pleckstrin homology like domain family B member 2
Aliases and Previous Symbols: N/A
Entrez ID: 90102
UniProt: Q86SQ0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5514
Expression level (log2 read counts): 5.03

Expression Distribution

negative regulation of wound healing, spreading of epidermal cells
regulation of basement membrane assembly involved in embryonic body morphogenesis
regulation of basement membrane organization
basal cortex
positive regulation of basement membrane assembly involved in embryonic body morphogenesis
regulation of wound healing, spreading of epidermal cells
negative regulation of morphogenesis of an epithelium
negative regulation of focal adhesion assembly
negative regulation of adherens junction organization
negative regulation of stress fiber assembly
positive regulation of extracellular matrix organization
negative regulation of cell junction assembly
negative regulation of actin filament bundle assembly
positive regulation of embryonic development
regulation of gastrulation
negative regulation of cell-matrix adhesion
regulation of extracellular matrix organization
cell leading edge
intermediate filament cytoskeleton
regulation of cell-substrate junction assembly
regulation of focal adhesion assembly
negative regulation of cell-substrate adhesion
regulation of adherens junction organization
negative regulation of wound healing
regulation of stress fiber assembly
regulation of epithelial to mesenchymal transition
negative regulation of response to wounding
regulation of cell junction assembly
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
regulation of cell-matrix adhesion
regulation of embryonic development
negative regulation of supramolecular fiber organization
regulation of wound healing
negative regulation of cytoskeleton organization
regulation of response to wounding
regulation of morphogenesis of an epithelium
regulation of microtubule cytoskeleton organization
regulation of cell-substrate adhesion
regulation of microtubule-based process