PHOSPHO1

Entrez Summary: N/A
UniProt Summary: Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

HAD
Put Phosphatase

phosphoethanolamine phosphatase activity
phosphocholine phosphatase activity
extracellular membrane-bounded organelle
pyrophosphatase activity
bone mineralization involved in bone maturation
ossification involved in bone maturation
phosphatidylethanolamine biosynthetic process
bone maturation
animal organ maturation
phosphatidylethanolamine metabolic process
replacement ossification
endochondral ossification
phosphatidylcholine biosynthetic process
bone mineralization
endochondral bone morphogenesis
regulation of bone mineralization
phosphatidylcholine metabolic process
regulation of biomineral tissue development
regulation of biomineralization
biomineral tissue development
biomineralization
bone morphogenesis
anatomical structure maturation
regulation of ossification
ammonium ion metabolic process
bone development
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
extracellular matrix
skeletal system morphogenesis
developmental maturation
phospholipid biosynthetic process
ossification
glycerophospholipid metabolic process
dephosphorylation
phospholipid metabolic process
glycerolipid metabolic process
skeletal system development
organophosphate biosynthetic process
lipid biosynthetic process