PI4K2A

Entrez Summary: N/A
UniProt Summary: Membrane-bound phosphatidylinositol-4 kinase (PI4- kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

growing cell tip
host cell presynaptic membrane
AP-3 adaptor complex binding
1-phosphatidylinositol 4-kinase activity
intrinsic component of membrane
BLOC-1 complex
phosphatidylinositol phosphorylation
lipid phosphorylation
presynaptic membrane
endosome organization
phosphatidylinositol biosynthetic process
Golgi organization
phosphatidylinositol metabolic process
trans-Golgi network
lipid modification
glycerophospholipid biosynthetic process
magnesium ion binding
glycerolipid biosynthetic process
membrane raft
phospholipid biosynthetic process
cytoplasmic vesicle
endosome
vesicle organization
lysosomal membrane
glycerophospholipid metabolic process
neuron projection
neuronal cell body
phospholipid metabolic process
glycerolipid metabolic process
endomembrane system organization
dendrite
organophosphate biosynthetic process
cell junction
lipid biosynthetic process
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process
mitochondrion
phosphorylation
integral component of plasma membrane