PIAS2

Gene Information

Official Symbol: PIAS2
Official Name: protein inhibitor of activated STAT 2
Aliases and Previous Symbols: N/A
Entrez ID: 9063
UniProt: O75928
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017].
UniProt Summary: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2- alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys- 160'. {ECO:0000269|PubMed:15920481, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:22406621}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15381
Expression level (log2 read counts): 6.01

Expression Distribution

SUMO ligase activity
negative regulation of androgen receptor signaling pathway
SUMO transferase activity
regulation of androgen receptor signaling pathway
androgen receptor signaling pathway
negative regulation of intracellular steroid hormone receptor signaling pathway
androgen receptor binding
RNA polymerase II transcription factor binding
protein sumoylation
intracellular steroid hormone receptor signaling pathway
regulation of intracellular steroid hormone receptor signaling pathway
transcription coregulator activity
PML body
steroid hormone mediated signaling pathway
intracellular receptor signaling pathway
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
transcription coactivator activity
ubiquitin protein ligase binding
peptidyl-lysine modification
response to steroid hormone
transcription factor binding
nuclear speck
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
protein modification by small protein conjugation
zinc ion binding
response to lipid
peptidyl-amino acid modification
response to hormone
response to organic cyclic compound
protein modification by small protein conjugation or removal
cellular response to endogenous stimulus
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
DNA binding
response to endogenous stimulus
positive regulation of transcription, DNA-templated