PIAS4 [The Human Chemical-Genetic Interaction Map Project]

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======= PIAS4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIAS4
  * **<color #00a2e8>Official Name</color>**: protein inhibitor of activated STAT 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51588|51588]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N2W9|Q8N2W9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIAS4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIAS4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605989|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-MIZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of keratinocyte apoptotic process|
|transferase complex|
|regulation of keratinocyte apoptotic process|
|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|SUMO ligase activity|
|positive regulation of protein sumoylation|
|vitamin D metabolic process|
|SUMO transferase activity|
|regulation of protein sumoylation|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|positive regulation of epithelial cell apoptotic process|
|fat-soluble vitamin metabolic process|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|double-strand break repair via nonhomologous end joining|
|regulation of tumor necrosis factor-mediated signaling pathway|
|positive regulation of intrinsic apoptotic signaling pathway|
|negative regulation of cytokine-mediated signaling pathway|
|RNA polymerase II transcription factor binding|
|non-recombinational repair|
|negative regulation of response to cytokine stimulus|
|protein sumoylation|
|regulation of epithelial cell apoptotic process|
|negative regulation of NF-kappaB transcription factor activity|
|transcription coregulator activity|
|positive regulation of response to DNA damage stimulus|
|PML body|
|nuclear matrix|
|vitamin metabolic process|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of intrinsic apoptotic signaling pathway|
|negative regulation of DNA-binding transcription factor activity|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of apoptotic signaling pathway|
|regulation of response to cytokine stimulus|
|double-strand break repair|
|protein C-terminus binding|
|regulation of response to DNA damage stimulus|
|regulation of protein modification by small protein conjugation or removal|
|transcription corepressor activity|
|steroid metabolic process|
|ubiquitin protein ligase binding|
|peptidyl-lysine modification|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of apoptotic signaling pathway|
|regulation of DNA-binding transcription factor activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|organic hydroxy compound metabolic process|
|DNA repair|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of cellular response to stress|
|DNA metabolic process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|positive regulation of intracellular signal transduction|
|cell-cell signaling|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|lipid metabolic process|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|small molecule metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.59|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.3|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.28|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.19|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.16|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.08|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.06|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.06|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.04|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.04|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.01|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.96|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.93|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.92|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.9|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.89|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.8|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.79|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.78|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.76|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.75|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.74|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.72|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.72|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.72|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:erg|ERG]]|0.437|
|[[:human genes:l:lmo2|LMO2]]|0.432|
|[[:human genes:s:shoc2|SHOC2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12535
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIAS4 Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>